The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State
Open accessAbstract
Despite a growing interest in CD4+ CD25+ regulatory T cells (Treg) that play a major role in self-tolerance and immunoregulation, fundamental parameters of the biology and homeostasis of these cells are poorly known. Here, we show that this population is composed of two Treg subsets that have distinct phenotypes and homeostasis in normal unmanipulated mice. In the steady state, some Treg remain quiescent and have a long lifespan, in the order of months, whereas the other Treg are dividing extensively and express multiple activation markers. After adoptive transfer, tissue-specific Treg rapidly divide and expand preferentially in lymph nodes draining their target self-antigens. These results reveal the existence of a cycling Treg subset composed of autoreactive Treg that are continuously activated by tissue self-antigens.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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An essential role for Scurfin in CD4+CD25+ T regulatory cells
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CD4+CD25+ suppressor T cells: more questions than answers
Shevach, E. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri821 · Cited by 2,110
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Self-citationCD4+CD25high Regulatory Cells in Human Peripheral Blood
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Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
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CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
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Cited by
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
Regulatory T cells in cancer immunotherapy
Tanaka, A., & Sakaguchi, S. (2017) · Cell Research · doi:10.1038/cr.2016.151 · Cited by 1,860
Regulatory T Cells and Human Disease
Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,120
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo
Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., & Khazaie, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408197102 · Cited by 806
mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
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Metadata
- Authors
- Fisson, S., Darrasse-Jèze, G., Litvinova, E., Septier, F., Klatzmann, D., Liblau, R., & Salomon, B. L.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-08-25
- Volume
- 198
- Issue
- 5
- Pages
- 737-746
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2117614250
- Cited by
- 522
- References
- 58
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fisson, S., Darrasse-Jèze, G., Litvinova, E., Septier, F., Klatzmann, D., Liblau, R., & Salomon, B. L. (2003). Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20030686
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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