The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR
Open accessAbstract
Thymocytes depend on the interaction with thymic epithelial cells for the generation of a diverse, nonautoreactive T cell repertoire. In turn, thymic epithelial cells acquire their three-dimensional cellular organization via instructive signals from developing thymocytes. The nature of these signals has been elusive so far. We show that thymocytes and medullary epithelial cells (MECs) communicate via the lymphotoxin β receptor (LTβR) signaling axis. Normal differentiation of thymic MECs requires LTβR ligand on thymocytes and LTβR together with nuclear factor–κB-inducing kinase (Nik) in thymic epithelial cells. Impaired lympho–epithelial cross talk in the absence of the LTβR causes aberrant differentiation and reduced numbers of thymic MECs, leads to the retention of mature T lymphocytes, and is associated with autoimmune phenomena, suggesting an unexpected role for LTβR signaling in central tolerance induction.
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Cited by
Akiyama, T., Shimo, Y., Yanai, H., Qin, J., Ohshima, D., Maruyama, Y., Asaumi, Y., Kitazawa, J., Takayanagi, H., Penninger, J. M., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.06.015 · Cited by 503
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The Mechanisms of T Cell Selection in the Thymus
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Metadata
- Authors
- Boehm, T., Scheu, S., Pfeffer, K., & Bleul, C. C.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-09-01
- Volume
- 198
- Issue
- 5
- Pages
- 757-769
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2150328261
- Cited by
- 369
- References
- 42
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Boehm, T., Scheu, S., Pfeffer, K., & Bleul, C. C. (2003). Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20030794
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