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Cited by 986

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin

De Togni, Pietro, Goellner, Joseph, Ruddle, Nancy H., Streeter, Philip R., Fick, Andrea, Mariathasan, Sanjeev, Smith, Stacy C., Carlson, Rebecca, Shornick, Laurie P., Strauss-Schoenberger, Jena, Russell, John H., Karr, Robert, Chaplin, David D.·1994·Science
DOI 10.1126/science.8171322
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Abstract

Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4 + CD8 - and CD4 - CD8 + T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.

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Metadata

Authors
De Togni, P., Goellner, J., Ruddle, N. H., Streeter, P. R., Fick, A., Mariathasan, S., Smith, S. C., Carlson, R., Shornick, L. P., Strauss-Schoenberger, J., Russell, J. H., Karr, R., & Chaplin, D. D.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-04-29
Volume
264
Issue
5159
Pages
703-707
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8171322
OpenAlex
W2041354260
Cited by
986
References
1
FWCI
18.21
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin. https://app.cochat.ai/papers/10.1126/science.8171322
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De Togni, P., Goellner, J., Ruddle, N. H., Streeter, P. R., Fick, A., Mariathasan, S., Smith, S. C., Carlson, R., Shornick, L. P., Strauss-Schoenberger, J., Russell, J. H., Karr, R., & Chaplin, D. D. (1994). Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin. Science. https://doi.org/10.1126/science.8171322

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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