The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
GATA-2 Plays Two Functionally Distinct Roles during the Ontogeny of Hematopoietic Stem Cells
Open accessAbstract
GATA-2 is an essential transcription factor in the hematopoietic system that is expressed in hematopoietic stem cells (HSCs) and progenitors. Complete deficiency of GATA-2 in the mouse leads to severe anemia and embryonic lethality. The role of GATA-2 and dosage effects of this transcription factor in HSC development within the embryo and adult are largely unexplored. Here we examined the effects of GATA-2 gene dosage on the generation and expansion of HSCs in several hematopoietic sites throughout mouse development. We show that a haploid dose of GATA-2 severely reduces production and expansion of HSCs specifically in the aorta-gonad-mesonephros region (which autonomously generates the first HSCs), whereas quantitative reduction of HSCs is minimal or unchanged in yolk sac, fetal liver, and adult bone marrow. However, HSCs in all these ontogenically distinct anatomical sites are qualitatively defective in serial or competitive transplantation assays. Also, cytotoxic drug-induced regeneration studies show a clear GATA-2 dose–related proliferation defect in adult bone marrow. Thus, GATA-2 plays at least two functionally distinct roles during ontogeny of HSCs: the production and expansion of HSCs in the aorta-gonad-mesonephros and the proliferation of HSCs in the adult bone marrow.
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Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., & Speck, N. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3444 · Cited by 1,178
Song, W.-J., Sullivan, M. G., Legare, R. D., Hutchings, S., Tan, X., Kufrin, D., Ratajczak, J., Resende, I. C., Haworth, C., Hock, R., et al. (1999) · Nature Genetics · doi:10.1038/13793 · Cited by 1,100
Cited by
Wilson, N. K., Foster, S. D., Wang, X., Knezevic, K., Schütte, J., Kaimakis, P., Chilarska, P. M., Kinston, S., Ouwehand, W. H., Dzierzak, E., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.016 · Cited by 728
Self-citationOf lineage and legacy: the development of mammalian hematopoietic stem cells
Dzierzak, E., & Speck, N. A. (2008) · Nature Immunology · doi:10.1038/ni1560 · Cited by 707
Self-citationA Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia
Gröschel, S., Sanders, M. A., Hoogenboezem, R., de Wit, E., Bouwman, B. A. M., Erpelinck, C., van der Velden, V. H. J., Havermans, M., Avellino, R., van Lom, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.02.019 · Cited by 687
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Induction of a hemogenic program in mouse fibroblasts
Pereira, C.-F., Chang, B., Qiu, J., Niu, X., Papatsenko, D., Hendry, C. E., Clark, N. R., Nomura-Kitabayashi, A., Kovacic, J. C., Ma’ayan, A., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.05.024 · Cited by 216
Ueda, Y., Cain, D. W., Kuraoka, M., Kondo, M., & Kelsoe, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803961 · Cited by 138
“We cultured 100 Flt3 LSK BM cells from naive and immunized (day 2) mice with SCF, IL-3, IL-6, and erythropoietin (32).”
MethodRossi, L., Lemoli, R. M., & Goodell, M. A. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2012.09.007 · Cited by 20
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Metadata
- Authors
- Ling, K.-W., Ottersbach, K., van Hamburg, J. P., Oziemlak, A., Tsai, F.-Y., Orkin, S. H., Ploemacher, R., Hendriks, R. W., & Dzierzak, E.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-10-04
- Volume
- 200
- Issue
- 7
- Pages
- 871-882
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2150731845
- Cited by
- 316
- References
- 2
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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