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Cellular Reprogramming of Human Peripheral Blood Cells

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Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs

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Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion

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The hemogenic endothelium: a critical source for the generation of PSC-derived hematopoietic stem and progenitor cells

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Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish

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Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors

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Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells

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Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence

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In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

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Generating human hematopoietic stem cells in vitro –exploring endothelial to hematopoietic transition as a portal for stemness acquisition

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PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells

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Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish

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Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies

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Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium

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Conversion of Human Fibroblasts Into Monocyte-Like Progenitor Cells

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The epigenetic basis of hematopoietic stem cell aging

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Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential

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Endothelial progenitors

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Transcription factor‐mediated reprogramming toward hematopoietic stem cells

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Engineering cell identity: establishing new gene regulatory and chromatin landscapes

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A Population of M2 Macrophages Associated With Bone Formation

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Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation

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Stem cell manipulation, gene therapy and the risk of cancer stem cell emergence

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Cell signaling pathways involved in hematopoietic stem cell specification

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Induced neuronal reprogramming

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Development of Hematopoietic Stem and Progenitor Cells From Human Pluripotent Stem Cells

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Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors

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Mechanism of hematopoiesis and vasculogenesis in mouse placenta

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Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources

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Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts

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The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State

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Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming

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Multifaceted Actions of GFI1 and GFI1B in Hematopoietic Stem Cell Self-Renewal and Lineage Commitment

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ETV6 and ETV7: Siblings in hematopoiesis and its disruption in disease

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Light-triggerable formulations for the intracellular controlled release of biomolecules

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In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma

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RUNX3-Mediated Immune Cell Development and Maturation

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GATA2 −/− human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment

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Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity

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Chemical Cocktail Induces Hematopoietic Reprogramming and Expands Hematopoietic Stem/Progenitor Cells

Zhou, Y., Zhu, X., Dai, Y., Xiong, S., Wei, C., Yu, P., Tang, Y., Wu, L., Li, J., Liu, D., et al. (2019) · Advanced Science · doi:10.1002/advs.201901785 · Cited by 28 · see citing works

A Stem Cell Perspective on Cellular Engineering

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Aging and Age-Related Epigenetic Drift in the Pathogenesis of Leukemia and Lymphomas: New Therapeutic Targets

Allegra, A., Caserta, S., Mirabile, G., & Gangemi, S. (2023) · Cells · doi:10.3390/cells12192392 · Cited by 29 · see citing works

A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations

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Making HSCs in vitro: don’t forget the hemogenic endothelium

Blaser, B. W., & Zon, L. I. (2018) · Blood · doi:10.1182/blood-2018-04-784140 · Cited by 25 · see citing works

Understanding and Modulating Immunity With Cell Reprogramming

Pires, C. F., Rosa, F. F., Kurochkin, I., & Pereira, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02809 · Cited by 27 · see citing works

Bioengineering Hematopoietic Stem Cell Niche toward Regenerative Medicine

Sugimura, R. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.010 · Cited by 24 · see citing works

Regulation of Blood Stem Cell Development

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Generation of patient specific human neural stem cells from Niemann-Pick disease type C patient-derived fibroblasts

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Transcription Factors Involved in Prostate Gland Adaptation to Androgen Deprivation

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New insights into the regulation by RUNX1 and GFI1(s) proteins of the endothelial to hematopoietic transition generating primordial hematopoietic cells

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An Expandable, Inducible Hemangioblast State Regulated by Fibroblast Growth Factor

Vereide, D. T., Vickerman, V., Swanson, S. A., Chu, L., McIntosh, B. E., & Thomson, J. A. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.10.003 · Cited by 20 · see citing works

Ihor R. Lemischka (1953–2017)

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Hematopoietic Reprogramming Entangles with Hematopoiesis

Wei, C., Yu, P., & Cheng, L. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.07.006 · Cited by 22 · see citing works

GATA2 mitotic bookmarking is required for definitive haematopoiesis

Silvério-Alves, R., Kurochkin, I., Rydström, A., Echegaray, C. V., Haider, J., Nicholls, M., Rode, C., Thelaus, L., Lindgren, A. Y., Ferreira, A. G., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40391-x · Cited by 22 · see citing works

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Daniel, M. G., Pereira, C., Bernitz, J. M., Lemischka, I. R., & Moore, K. A. (2016) · Journal of Visualized Experiments · doi:10.3791/54372 · Cited by 1 · see citing works

Research Highlights

(2013) · Molecular Therapy · doi:10.1038/mt.2013.127

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

Silvério-Alves, R., Gomes, A. M., Kurochkin, I., Moore, K. A., & Pereira, C. (2019) · Journal of Visualized Experiments · doi:10.3791/60112-v · Cited by 1 · see citing works

Investigador Auxiliar

Gomes, A. (2018) · Estudo Geral (Universidad de Coimbra)

Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture

Daniel, M. G., Sachs, D. M., Bernitz, J. M., Fstkchyan, Y. S., Rapp, K., Satija, N., Law, K., Patel, F., Gomes, A. M., Kim, H., et al. (2019) · FEBS Letters · doi:10.1002/1873-3468.13621 · Cited by 16 · see citing works