The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters
Open accessAbstract
Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in animal studies. Analysis of promiscuous gene expression in purified stromal cells of the human thymus at the single and global gene level documents the species conservation of this phenomenon. Medullary thymic epithelial cells overexpress a highly diverse set of genes (>400) including many tissue-specific antigens, disease-associated autoantigens, and cancer-germline genes. Although there are no apparent structural or functional commonalities among these genes and their products, they cluster along chromosomes. These findings have implications for human autoimmune diseases, immuno-therapy of tumors, and the understanding of the nature of this unorthodox regulation of gene expression.
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Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L. J., Bartlett, R. J., Ricordi, C., Pietropaolo, M., Eisenbarth, G. S., Bennett, S. T., & Patel, D. D. (1997) · Nature Genetics · doi:10.1038/ng0397-293 · Cited by 945
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
Vafiadis, P., Bennett, S. T., Todd, J. A., Nadeau, J., Grabs, R., Goodyer, C. G., Wickramasinghe, S., Colle, E., & Polychronakos, C. (1997) · Nature Genetics · doi:10.1038/ng0397-289 · Cited by 809 · cited 1×
“This will be a prerequisite to establish a database on promiscuous gene expression in humans, thereby documenting interindividual differences (11, 14), allelic polymorphisms (40, 41), and splice variants (55).”
Background
Cited by
Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation
Gallegos, A. M., & Bevan, M. J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041457 · Cited by 490
The determinants of tumour immunogenicity
Blankenstein, T., Coulie, P. G., Gilboa, E., & Jaffee, E. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3246 · Cited by 441
Self-representation in the thymus: an extended view
Kyewski, B., & Derbinski, J. (2004) · Nature Reviews Immunology · doi:10.1038/nri1436 · Cited by 342
Self-citationImpaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans
Lv, H., Havari, E., Pinto, S., Gottumukkala, R. V. S. R. K., Cornivelli, L., Raddassi, K., Matsui, T., Rosenzweig, A., Bronson, R. T., Smith, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44583 · Cited by 228
Self-citationMathis, D., & Benoist, C. (2004) · Immunity · doi:10.1016/s1074-7613(04)00111-6 · Cited by 198
Metadata
- Authors
- Gotter, J., Brors, B., Hergenhahn, M., & Kyewski, B.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-01-19
- Volume
- 199
- Issue
- 2
- Pages
- 155-166
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2121733174
- Cited by
- 359
- References
- 2
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gotter, J., Brors, B., Hergenhahn, M., & Kyewski, B. (2004). Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20031677
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