The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen
Open accessAbstract
Tolerance is the usual outcome of inhalation of harmless antigen, yet T helper (Th) type 2 cell sensitization to inhaled allergens induced by dendritic cells (DCs) is common in atopic asthma. Here, we show that both myeloid (m) and plasmacytoid (p) DCs take up inhaled antigen in the lung and present it in an immunogenic or tolerogenic form to draining node T cells. Strikingly, depletion of pDCs during inhalation of normally inert antigen led to immunoglobulin E sensitization, airway eosinophilia, goblet cell hyperplasia, and Th2 cell cytokine production, cardinal features of asthma. Furthermore, adoptive transfer of pDCs before sensitization prevented disease in a mouse asthma model. On a functional level, pDCs did not induce T cell division but suppressed the generation of effector T cells induced by mDCs. These studies show that pDCs provide intrinsic protection against inflammatory responses to harmless antigen. Therapies exploiting pDC function might be clinically effective in preventing the development of asthma.
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Citations
Cites
The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.284.5421.1835 · Cited by 2,293
Brown, J. A., Dorfman, D. M., Ma, F.-R., Sullivan, E. L., Munoz, O., Wood, C. R., Greenfield, E. A., & Freeman, G. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1257 · Cited by 968
Cited by
Lambrecht, B. N., & Hammad, H. (2015) · Nature Immunology · doi:10.1038/ni.3049 · Cited by 1,673
Self-citationMonocyte differentiation and antigen-presenting functions
Jakubzick, C. V., Randolph, G. J., & Henson, P. M. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.28 · Cited by 910
The development and function of lung-resident macrophages and dendritic cells
Kopf, M., Schneider, C., & Nobs, S. P. (2015) · Nature Immunology · doi:10.1038/ni.3052 · Cited by 555
Regulation of immunological homeostasis in the respiratory tract
Holt, P. G., Strickland, D. H., Wikström, M. E., & Jahnsen, F. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2236 · Cited by 528
Dendritic Cell Regulation of T Helper Cells
Yin, X., Chen, S., & Eisenbarth, S. C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-025146 · Cited by 447
Metadata
- Authors
- de Heer, H. J., Hammad, H., Soullié, T., Hijdra, D., Vos, N., Willart, M. A. M., Hoogsteden, H. C., & Lambrecht, B. N.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-07-05
- Volume
- 200
- Issue
- 1
- Pages
- 89-98
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2158722408
- Cited by
- 785
- References
- 2
- FWCI
- 34.00
- Type
- journal article
- Language
- en
- Open access
- green
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- de Heer, H. J., Hammad, H., Soullié, T., Hijdra, D., Vos, N., Willart, M. A. M., Hoogsteden, H. C., & Lambrecht, B. N. (2004). Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20040035
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