Regulation of immunological homeostasis in the respiratory tract

Holt, Patrick G.; Strickland, Deborah H.; Wikström, Matthew E.; Jahnsen, Frode L.

doi:10.1038/nri2236

Cited by 528T-cell and B-cell ImmunologyAsthma and respiratory diseasesImmune Response and Inflammation

Regulation of immunological homeostasis in the respiratory tract

Holt, Patrick G., Strickland, Deborah H., Wikström, Matthew E., Jahnsen, Frode L.·2008·Nature Reviews Immunology

DOI 10.1038/nri2236

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Abstract

The respiratory tract has an approximate surface area of 70 m2 in adult humans, which is in virtually direct contact with the outside environment. It contains a uniquely rich vascular bed containing a large pool of marginated T cells, and harbours a layer of single-cell-thick epithelial tissue through which re-oxygenation of blood must occur uninterrupted for survival. It is therefore not surprising that the respiratory tract is never more than a short step away from disaster. We have only a partial understanding of how immunological homeostasis is maintained in these tissues, but it is becoming clear that the immune system has evolved a range of specific mechanisms to deal with the unique problems encountered in this specialized microenvironment.

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Respiratory viruses can induce cytotoxicity of airway epithelial cells by increased cell apoptosis.
“Respiratory viruses can also induce cytotoxicity of airway epithelial cells by increased cell apoptosis.”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [116]
Respiratory viruses may lead directly to exaggerated cell apoptosis.
“Respiratory viruses may lead directly to exaggerated cell apoptosis (116, 186)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [116]

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Authors: Holt, P. G., Strickland, D. H., Wikström, M. E., & Jahnsen, F. L.
Affiliations: The Kids Research Institute Australia (AU)
University of Oslo (NO)
Corresponding author: Holt, Patrick G.
ORCID: Holt, Patrick G.
Strickland, Deborah H.
Wikström, Matthew E.
Jahnsen, Frode L.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-02
Volume: 8
Issue: 2
Pages: 142-152
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2236
OpenAlex: W1991309663
Cited by: 528
References: 106
Citations by year: 2026: 14 · 2025: 9 · 2024: 16 · 2023: 14 · 2022: 28 · 2021: 26 · 2020: 29 · 2019: 18 · 2018: 23 · 2017: 22 · 2016: 27 · 2015: 34 · 2014: 34 · 2013: 48 · 2012: 45
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: immune homeostasis, respiratory tract, lung immunity, airway epithelium, mucosal immunity, lung microenvironment
MeSH terms: Cell Movement, Homeostasis, Humans, Lung, T-Lymphocytes, Respiratory Mucosa

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Regulation of immunological homeostasis in the respiratory tract

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