The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Defective B cell tolerance checkpoints in systemic lupus erythematosus
Open accessAbstract
A cardinal feature of systemic lupus erythematosus (SLE) is the development of autoantibodies. The first autoantibodies described in patients with SLE were those specific for nuclei and DNA, but subsequent work has shown that individuals with this disease produce a panoply of different autoantibodies. Thus, one of the constant features of SLE is a profound breakdown in tolerance in the antibody system. The appearance of self-reactive antibodies in SLE precedes clinical disease, but where in the B cell pathway tolerance is first broken has not been defined. In healthy humans, autoantibodies are removed from the B cell repertoire in two discrete early checkpoints in B cell development. We found these checkpoints to be defective in three adolescent patients with SLE. 25–50% of the mature naive B cells in SLE patients produce self-reactive antibodies even before they participate in immune responses as compared with 5–20% in controls. We conclude that SLE is associated with abnormal early B cell tolerance.
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Cites
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Cited by
Toll-like receptors in systemic autoimmune disease
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Self-citationType I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases
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Self-citationAutoimmunity and organ damage in systemic lupus erythematosus
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Metadata
- Authors
- Yurasov, S., Wardemann, H., Hammersen, J., Tsuiji, M., Meffre, E., Pascual, V., & Nussenzweig, M. C.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-02-28
- Volume
- 201
- Issue
- 5
- Pages
- 703-711
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2127132484
- Cited by
- 717
- References
- 60
- FWCI
- 24.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Yurasov, S., Wardemann, H., Hammersen, J., Tsuiji, M., Meffre, E., Pascual, V., & Nussenzweig, M. C. (2005). Defective B cell tolerance checkpoints in systemic lupus erythematosus. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20042251
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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