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Cited by 391

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection

Open access
Glass, William G., Lim, Jean K., Cholera, Rushina, Pletnev, Alexander G., Gao, Ji-Liang, Murphy, Philip M.·2005·The Journal of Experimental Medicine
DOI 10.1084/jem.20042530
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Abstract

The molecular immunopathogenesis of West Nile virus (WNV) infection is poorly understood. Here, we characterize a mouse model for WNV using a subcutaneous route of infection and delineate leukocyte subsets and immunoregulatory factors present in the brains of infected mice. Central nervous system (CNS) expression of the chemokine receptor CCR5 and its ligand CCL5 was prominently up-regulated by WNV, and this was associated with CNS infiltration of CD4+ and CD8+ T cells, NK1.1+ cells and macrophages expressing the receptor. The significance of CCR5 in pathogenesis was established by mortality studies in which infection of CCR5−/− mice was rapidly and uniformly fatal. In the brain, WNV-infected CCR5−/− mice had increased viral burden but markedly reduced NK1.1+ cells, macrophages, and CD4+ and CD8+ T cells compared with WNV-infected CCR5+/+ mice. Adoptive transfer of splenocytes from WNV-infected CCR5+/+ mice into infected CCR5−/− mice increased leukocyte accumulation in the CNS compared with transfer of splenocytes from infected CCR5−/− mice into infected CCR5−/− mice, and increased survival to 60%, the same as in infected CCR5+/+ control mice. We conclude that CCR5 is a critical antiviral and survival determinant in WNV infection of mice that acts by regulating trafficking of leukocytes to the infected brain.

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Metadata

Authors
Glass, W. G., Lim, J. K., Cholera, R., Pletnev, A. G., Gao, J.-L., & Murphy, P. M.
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2005-10-17
Volume
202
Issue
8
Pages
1087-1098
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.20042530
OpenAlex
W2120996101
Cited by
391
References
35
FWCI
23.94
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. https://app.cochat.ai/papers/10.1084/jem.20042530
The paper
Glass, W. G., Lim, J. K., Cholera, R., Pletnev, A. G., Gao, J.-L., & Murphy, P. M. (2005). Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20042530

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.