The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A Critical Role for Induced IgM in the Protection against West Nile Virus Infection
Open accessAbstract
In humans, the elderly and immunocompromised are at greatest risk for disseminated West Nile virus (WNV) infection, yet the immunologic basis for this remains unclear. We demonstrated previously that B cells and IgG contributed to the defense against disseminated WNV infection (Diamond, M.S., B. Shrestha, A. Marri, D. Mahan, and M. Engle. 2003. J. Virol. 77:2578–2586). In this paper, we addressed the function of IgM in controlling WNV infection. C57BL/6J mice (sIgM−/−) that were deficient in the production of secreted IgM but capable of expressing surface IgM and secreting other immunoglobulin isotypes were vulnerable to lethal infection, even after inoculation with low doses of WNV. Within 96 h, markedly higher levels of infectious virus were detected in the serum of sIgM−/− mice compared with wild-type mice. The enhanced viremia correlated with higher WNV burdens in the central nervous system, and was also associated with a blunted anti-WNV IgG response. Passive transfer of polyclonal anti-WNV IgM or IgG protected sIgM−/− mice against mortality, although administration of comparable amounts of a nonneutralizing monoclonal anti-WNV IgM provided no protection. In a prospective analysis, a low titer of anti-WNV IgM antibodies at day 4 uniformly predicted mortality in wild-type mice. Thus, the induction of a specific, neutralizing IgM response early in the course of WNV infection limits viremia and dissemination into the central nervous system, and protects against lethal infection.
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The logical analysis of continuous, non-linear biochemical control networks
Glass, L., & Kauffman, S. A. (1973) · Journal of Theoretical Biology · doi:10.1016/0022-5193(73)90208-7 · Cited by 940
Saurwein-Teissl, M., Lung, T. L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5893 · Cited by 499
The Effect of Age on the B-Cell Repertoire
Weksler, M. E., & Szabo, P. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1006659401385 · Cited by 205
West Nile virus neuroinvasion and encephalitis induced by macrophage depletion in mice
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Cited by
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
Wang, T., Town, T., Alexopoulou, L., Anderson, J. F., Fikrig, E., & Flavell, R. A. (2004) · Nature Medicine · doi:10.1038/nm1140 · Cited by 1,155
Solomon, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030476 · Cited by 394
Glass, W. G., Lim, J. K., Cholera, R., Pletnev, A. G., Gao, J.-L., & Murphy, P. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042530 · Cited by 391
West Nile virus neuroinvasive disease
Davis, L. E., DeBiasi, R., Goade, D. E., Haaland, K. Y., Harrington, J. A., Harnar, J. B., Pergam, S. A., King, M. K., DeMasters, B. K., & Tyler, K. L. (2006) · Annals of Neurology · doi:10.1002/ana.20959 · Cited by 388
Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection
Daffis, S., Samuel, M. A., Suthar, M. S., Gale, M., & Diamond, M. S. (2008) · Journal of Virology · doi:10.1128/jvi.00935-08 · Cited by 358
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Metadata
- Authors
- Diamond, M. S., Sitati, E. M., Friend, L. D., Higgs, S., Shrestha, B., & Engle, M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-12-08
- Volume
- 198
- Issue
- 12
- Pages
- 1853-1862
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2109403620
- Cited by
- 303
- References
- 6
- FWCI
- 16.15
- Type
- journal article
- Language
- en
- Open access
- green
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