T cell responses in the central nervous system

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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The amyloid hypothesis of Alzheimer's disease at 25 years

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Sleep Drives Metabolite Clearance from the Adult Brain

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Structure and function of the blood–brain barrier

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The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

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IL-17 and th17 cells

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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Structural and functional features of central nervous system lymphatic vessels

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments

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The role of inflammation in depression: from evolutionary imperative to modern treatment target

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The expanding universe of T-cell subsets: Th1, Th2 and more

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Host microbiota constantly control maturation and function of microglia in the CNS

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

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Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

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Immune attack: the role of inflammation in Alzheimer disease

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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

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Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

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Establishment and Dysfunction of the Blood-Brain Barrier

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LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan

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Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

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Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

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Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology

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Antigen-specific interaction between T and B cells

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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

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The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

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Functional Specialization of Interleukin-17 Family Members

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Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

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The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

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Origin, fate and dynamics of macrophages at central nervous system interfaces

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C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

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RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

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FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

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Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

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T‐lymphocyte entry into the central nervous system

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Fate mapping of IL-17-producing T cells in inflammatory responses

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Induction and molecular signature of pathogenic TH17 cells

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A Validated Regulatory Network for Th17 Cell Specification

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Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

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IFN-γ-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking

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The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

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Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

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IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

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Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

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Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

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The alarmin IL-33 promotes regulatory T-cell function in the intestine

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Noncytolytic Control of Viral Infections by the Innate and Adaptive ImmuneResponse

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Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

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The anatomical and cellular basis of immune surveillance in the central nervous system

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Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

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Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine

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T-cell activation by transitory neo-antigens derived from distinct microbial pathways

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Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

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Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis

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Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

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Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets

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Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis

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Extrathymically generated regulatory T cells control mucosal TH2 inflammation

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Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

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Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

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Regulation of learning and memory by meningeal immunity: a key role for IL-4

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Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

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Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

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The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

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Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

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Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis

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What is immune privilege (not)?

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Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

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Resident memory CD8 T cells trigger protective innate and adaptive immune responses

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Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

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Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis

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Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

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Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions.

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