The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The immune paradox of sarcoidosis and regulatory T cells
Open accessAbstract
Sarcoidosis is characterized by extensive local inflammation (granuloma, cytokine secretion) associated with anergy (poor response to antigens in vitro and in vivo). We postulated that this paradoxical situation would correspond to a disequilibrium between effector and regulatory T lymphocytes (T reg cells). We show that CD4+CD25brightFoxP3+ cells accumulate at the periphery of sarcoid granulomas, in bronchoalveolar lavage fluid, and in peripheral blood of patients with active disease. These cells exhibited powerful antiproliferative activity, yet did not completely inhibit TNF-α production. Sarcoidosis is therefore associated with a global T reg cell subset amplification whose activity would be insufficient to control local inflammation. At the same time, peripheral T reg cells exert powerful antiproliferative activity that may account for the state of anergy. Altogether, these findings advance our conceptual understanding of immune regulation in a way that resolves the immune paradox of sarcoidosis and permit us to envisage a profound clinical impact of T reg cell manipulation on immunity.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608
Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151
Cited by
Miyara, M., Yoshioka, Y., Kitoh, A., Shima, T., Wing, K., Niwa, A., Parizot, C., Taflin, C., Heike, T., Valeyre, D., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.019 · Cited by 2,291
Self-citationValeyre, D., Prasse, A., Nunes, H., Uzunhan, Y., Brillet, P.-Y., & Müller-Quernheim, J. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60680-7 · Cited by 1,087
Self-citationHodi, F. S., Butler, M., Oble, D. A., Seiden, M. V., Haluska, F. G., Kruse, A., MacRae, S., Nelson, M., Canning, C., Lowy, I., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712237105 · Cited by 650
1,25‐dihydroxyvitamin D 3 promotes IL‐10 production in human B cells
Heine, G., Niesner, U., Chang, H., Steinmeyer, A., Zügel, U., Zuberbier, T., Radbruch, A., & Worm, M. (2008) · European Journal of Immunology · doi:10.1002/eji.200838216 · Cited by 311
Inflammatory Cardiomyopathic Syndromes
Trachtenberg, B. H., & Hare, J. M. (2017) · Circulation Research · doi:10.1161/circresaha.117.310221 · Cited by 289
Metadata
- Authors
- Miyara, M., Amoura, Z., Parizot, C., Badoual, C., Dorgham, K., Trad, S., Kambouchner, M., Valeyre, D., Chapelon-Abric, C., Debré, P., Piette, J.-C., & Gorochov, G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2006-01-23
- Volume
- 203
- Issue
- 2
- Pages
- 359-370
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2165779188
- Cited by
- 450
- References
- 4
- FWCI
- 18.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Miyara, M., Amoura, Z., Parizot, C., Badoual, C., Dorgham, K., Trad, S., Kambouchner, M., Valeyre, D., Chapelon-Abric, C., Debré, P., Piette, J.-C., & Gorochov, G. (2006). The immune paradox of sarcoidosis and regulatory T cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20050648
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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