The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Regulation of innate and adaptive immunity by Notch
Open accessAbstract
Coordinated function of the innate and adaptive arms of the immune system in vertebrates is essential to promote protective immunity and to avoid immunopathology. The Notch signalling pathway, which was originally identified as a pleiotropic mediator of cell fate in invertebrates, has recently emerged as an important regulator of immune cell development and function. Notch was initially shown to be a key determinant of cell-lineage commitment in developing lymphocytes, but it is now known to control the homeostasis of several innate cell populations. Moreover, the roles of Notch in adaptive immunity have expanded to include the regulation of T cell differentiation and function. The aim of this Review is to summarize the current status of immune regulation by Notch. A better understanding of Notch function in both innate and adaptive immunity will hopefully provide multiple avenues for therapeutic intervention in disease.
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Innate lymphoid cells — a proposal for uniform nomenclature
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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
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Cited by
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
Notch Signaling in the Tumor Microenvironment
Meurette, O., & Mehlen, P. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.07.009 · Cited by 678
TH2 cell development and function
Walker, J. A., & McKenzie, A. N. J. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.118 · Cited by 632
γ-secretase directly sheds the survival receptor BCMA from plasma cells
Laurent, S. A., Hoffmann, F. S., Kuhn, P.-H., Cheng, Q., Chu, Y., Schmidt-Supprian, M., Hauck, S. M., Schuh, E., Krumbholz, M., Rübsamen, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8333 · Cited by 377
Developmental gene networks: a triathlon on the course to T cell identity
Yui, M. A., & Rothenberg, E. V. (2014) · Nature Reviews Immunology · doi:10.1038/nri3702 · Cited by 342
Metadata
- Authors
- Radtke, F., MacDonald, H. R., & Tacchini-Cottier, F.
- Venue
- Nature Reviews Immunology
- Published
- 2013-05-13
- Volume
- 13
- Issue
- 6
- Pages
- 427-437
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2159662576
- Cited by
- 401
- References
- 118
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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