The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
Open accessAbstract
Deoxyribonuclease (DNase) II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. DNase II–deficient mouse embryos accumulate undigested DNA in macrophages, and die in feto because of the activation of the interferon β (IFNβ) gene. Here, we found that the F4/80-positive macrophages in DNase II−/− fetal liver specifically produce a set of cytokines such as IFNβ, TNFα, and CXCL10. Whereas, IFN-inducible genes (2′5′-oligo(A) synthetase, IRF7, and ISG15) were expressed not only in macrophages but also in other F4/80-negative cells. When DNase II−/− macrophages or embryonal fibroblasts engulfed apoptotic cells, they expressed the IFNβ and CXCL10 genes. The ablation of Toll-like receptor (TLR) 3 and 9, or their adaptor molecules (MyD88 and TRIF), had no effect on the lethality of the DNase II−/− mice. These results indicate that there is a TLR-independent sensing mechanism to activate the innate immunity for the endogenous DNA escaping lysosomal degradation.
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Cites
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Self-citationA Toll-like receptor recognizes bacterial DNA
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“This finding led to the proposal that the unmethylated CpG motif that is abundant in the bacterial genome is responsible for the induction of innate immunity by DNA (10); and, this idea was supported by the observation that TLR9 recognizes this DNA motif (20).”
BackgroundSelf-citationRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
IRF Family of Transcription Factors as Regulators of Host Defense
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Self-citationIdentification of a factor that links apoptotic cells to phagocytes
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Self-citationPhosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells
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Self-citationRecognition of microorganisms and activation of the immune response
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Metadata
- Authors
- Okabe, Y., Kawane, K., Akira, S., Taniguchi, T., & Nagata, S.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-11-21
- Volume
- 202
- Issue
- 10
- Pages
- 1333-1339
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2102572106
- Cited by
- 275
- References
- 7
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Okabe, Y., Kawane, K., Akira, S., Taniguchi, T., & Nagata, S. (2005). Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20051654
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