The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens
Open accessAbstract
Natural regulatory T (T reg) cells are involved in control of the immune response, including response to pathogens. Previous work has demonstrated that the repertoire of natural T reg cells may be biased toward self-antigen recognition. Whether they also recognize foreign antigens and how this recognition contributes to their function remain unknown. Our studies addressed the antigenic specificity of natural T reg cells that accumulate at sites of chronic infection with Leishmania major in mice. Our results support the idea that natural T reg cells are able to respond specifically to foreign antigens in that they strongly proliferate in response to Leishmania-infected dendritic cells, they maintain Foxp3 expression, and Leishmania-specific T reg cell lines can be generated from infected mice. Surprisingly, the majority of natural T reg cells at the infected site are Leishmania specific. Further, we showed that parasite-specific natural T reg cells are restricted to sites of infection and that their survival is strictly dependent on parasite persistence.
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Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
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CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
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Self-citationNatural versus adaptive regulatory T cells
Bluestone, J. A., & Abbas, A. K. (2003) · Nature Reviews Immunology · doi:10.1038/nri1032 · Cited by 1,323
In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes
Tang, Q., Henriksen, K. J., Bi, M., Finger, E. B., Szot, G., Ye, J., Masteller, E. L., McDevitt, H., Bonyhadi, M., & Bluestone, J. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040139 · Cited by 1,221
Natural regulatory T cells in infectious disease
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Self-citationRegulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide
Caramalho, I., Lopes-Carvalho, T., Ostler, D., Zelenay, S., Haury, M., & Demengeot, J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021633 · Cited by 970
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Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells
Mottet, C., Uhlig, H. H., & Powrie, F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.3939 · Cited by 927
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Munn, D. H., & Mellor, A. L. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.10.001 · Cited by 1,037
Regulatory T cells and infection: a dangerous necessity
Belkaid, Y. (2007) · Nature Reviews Immunology · doi:10.1038/nri2189 · Cited by 745
Self-citationTreg cell-based therapies: challenges and perspectives
Raffin, C., Vo, L. T., & Bluestone, J. A. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0232-6 · Cited by 720
How do Regulatory T Cells Work?
Corthay, A. (2009) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2009.02308.x · Cited by 648
Metadata
- Authors
- Suffia, I. J., Reckling, S. K., Piccirillo, C. A., Goldszmid, R. S., & Belkaid, Y.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2006-03-13
- Volume
- 203
- Issue
- 3
- Pages
- 777-788
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2023659884
- Cited by
- 311
- References
- 40
- FWCI
- 15.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Suffia, I. J., Reckling, S. K., Piccirillo, C. A., Goldszmid, R. S., & Belkaid, Y. (2006). Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20052056
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
