The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells
Abstract
CD4+CD25+ regulatory T cells have been shown to prevent T cell-mediated immune pathology; however, their ability to ameliorate established inflammation has not been tested. Using the CD4+CD45RBhigh T cell transfer model of inflammatory bowel disease, we show that CD4+CD25+ but not CD4+CD25−CD45RBlow T cells are able to cure intestinal inflammation. Transfer of CD4+CD25+ T cells into mice with colitis led to resolution of the lamina propria infiltrate in the intestine and reappearance of normal intestinal architecture. CD4+CD25+ T cells were found to proliferate in the mesenteric lymph nodes and inflamed colon. They were located between clusters of CD11c+ cells and pathogenic T cells and found to be in contact with both cell types. These studies suggest that manipulation of CD4+CD25+ T cells may be beneficial in the treatment of chronic inflammatory diseases.
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Citations
Cites
Powrie, F., Leach, M. W., Mauze, S., Menon, S., Barcomb Caddle, L., & Coffman, R. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90045-0 · Cited by 1,146
Self-citationPowrie, F., Leach, M. W., Mauze, S., Caddie, L. B., & Coffman, R. L. (1993) · International Immunology · doi:10.1093/intimm/5.11.1461 · Cited by 1,078
Self-citation
Cited by
The immunological and genetic basis of inflammatory bowel disease
Bouma, G., & Strober, W. (2003) · Nature Reviews Immunology · doi:10.1038/nri1132 · Cited by 1,767
Immunopathogenesis of IBD: current state of the art
de Souza, H. S. P., & Fiocchi, C. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.186 · Cited by 1,551
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193
Beck, K. E., Blansfield, J. A., Tran, K. Q., Feldman, A. L., Hughes, M. S., Royal, R. E., Kammula, U. S., Topalian, S. L., Sherry, R. M., Kleiner, D., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.5716 · Cited by 833
Yadav, M., Louvet, C., Davini, D., Gardner, J. M., Martinez-Llordella, M., Bailey-Bucktrout, S., Anthony, B. A., Sverdrup, F. M., Head, R., Kuster, D. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120822 · Cited by 649
Metadata
- Authors
- Mottet, C., Uhlig, H. H., & Powrie, F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-04
- Volume
- 170
- Issue
- 8
- Pages
- 3939-3943
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1545517148
- Cited by
- 927
- References
- 2
- FWCI
- 22.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mottet, C., Uhlig, H. H., & Powrie, F. (2003). Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.170.8.3939
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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