The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
Open accessAbstract
Nippostrongylus brasiliensis infection and ovalbumin-induced allergic lung pathology are highly interleukin (IL)-4/IL-13 dependent, but the contributions of IL-4/IL-13 from adaptive (T helper [Th]2 cells) and innate (eosinophil, basophils, and mast cells) immune cells remain unknown. Although required for immunoglobulin (Ig)E induction, IL-4/IL-13 from Th2 cells was not required for worm expulsion, tissue inflammation, or airway hyperreactivity. In contrast, innate hematopoietic cell–derived IL-4/IL-13 was dispensable for Th2 cell differentiation in lymph nodes but required for effector cell recruitment and tissue responses. Eosinophils were not required for primary immune responses. Thus, components of type 2 immunity mediated by IL-4/IL-13 are partitioned between T cell–dependent IgE and an innate non-eosinophil tissue component, suggesting new strategies for interventions in allergic immunity.
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Yu, C., Cantor, A. B., Yang, H., Browne, C., Wells, R. A., Fujiwara, Y., & Orkin, S. H. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020656 · Cited by 600 · cited 3×
“However, a potential role of eosinophils could be analyzed using IL-5tg mice (20), which produce massive numbers of eosinophils, and ∆dblGATA mice (21), which lack eosinophils due to a mutation of a GATA-1 binding site in the gata-1 promoter.”
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Cited by
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Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
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Self-citationMolofsky, A. B., Nussbaum, J. C., Liang, H.-E., Van Dyken, S. J., Cheng, L. E., Mohapatra, A., Chawla, A., & Locksley, R. M. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121964 · Cited by 874
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Metadata
- Authors
- Voehringer, D., Reese, T. A., Huang, X., Shinkai, K., & Locksley, R. M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2006-05-15
- Volume
- 203
- Issue
- 6
- Pages
- 1435-1446
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2142899869
- Cited by
- 348
- References
- 1
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Voehringer, D., Reese, T. A., Huang, X., Shinkai, K., & Locksley, R. M. (2006). Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20052448
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