The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Importance of group X–secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model
Open accessAbstract
Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma. The availability of free arachidonate in cells for subsequent eicosanoid biosynthesis is controlled by phospholipase A2s (PLA2s), most notably cytosolic PLA2-α. 10 secreted PLA2s (sPLA2s) have also been identified, but their function in eicosanoid generation is poorly understood. We investigated the role of group X sPLA2 (sPLA2-X), the sPLA2 with the highest in vitro cellular phospholipolysis activity, in acute and chronic mouse asthma models in vivo. The lungs of sPLA2-X−/− mice, compared with those of sPLA2-X+/+ littermates, had significant reduction in ovalbumin-induced infiltration by CD4+ and CD8+ T cells and eosinophils, goblet cell metaplasia, smooth muscle cell layer thickening, subepithelial fibrosis, and levels of T helper type 2 cell cytokines and eicosanoids. These data direct attention to sPLA2-X as a novel therapeutic target for asthma.
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Kay, A. B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440106 · Cited by 1,368
Lee, C. G., Homer, R. J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V., Shipley, J. M., Gotwals, P., Noble, P., Chen, Q., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.809 · Cited by 940
Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-β
Asakura, T., Ishii, Y., Chibana, K., & Fukuda, T. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.04.037 · Cited by 51
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Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586
Self-citationDennis, E. A., Cao, J., Hsu, Y.-H., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,203
Peters-Golden, M., & Henderson, W. R. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071371 · Cited by 1,013
Self-citationBiochemistry and Physiology of Mammalian Secreted Phospholipases A2
Lambeau, G., & Gelb, M. H. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.062405.154007 · Cited by 513
Self-citationInhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
Henderson, W. R., Chi, E. Y., Ye, X., Nguyen, C., Tien, Y.-T., Zhou, B., Borok, Z., Knight, D. A., & Kahn, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001520107 · Cited by 462
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Metadata
- Authors
- Henderson, W. R., Chi, E. Y., Bollinger, J. G., Tien, Y.-T., Ye, X., Castelli, L., Rubtsov, Y. P., Singer, A. G., Chiang, G. K. S., Nevalainen, T., Rudensky, A. Y., & Gelb, M. H.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2007-04-02
- Volume
- 204
- Issue
- 4
- Pages
- 865-877
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2122979826
- Cited by
- 188
- References
- 3
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Henderson, W. R., Chi, E. Y., Bollinger, J. G., Tien, Y.-T., Ye, X., Castelli, L., Rubtsov, Y. P., Singer, A. G., Chiang, G. K. S., Nevalainen, T., Rudensky, A. Y., & Gelb, M. H. (2007). Importance of group X–secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20070029
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
