The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2
Open accessAbstract
Symptomatic primary Epstein-Barr virus (EBV) infection and elevated humoral immune responses to EBV are associated with an increased risk of developing multiple sclerosis (MS). We explored mechanisms leading to this change in EBV-specific immunity in untreated patients with MS and healthy virus carriers matched for MS-associated HLA alleles. MS patients showed selective increase of T cell responses to the EBV nuclear antigen 1 (EBNA1), the most consistently recognized EBV-derived CD4+ T cell antigen in healthy virus carriers, but not to other EBV-encoded proteins. In contrast, influenza and human cytomegalovirus–specific immune control was unchanged in MS. The enhanced response to EBNA1 was mediated by an expanded reservoir of EBNA1-specific central memory CD4+ T helper 1 (Th1) precursors and Th1 (but not Th17) polarized effector memory cells. In addition, EBNA1-specific T cells recognized myelin antigens more frequently than other autoantigens that are not associated with MS. Myelin cross-reactive T cells produced IFN-γ, but differed from EBNA1-monospecific cells in their capability to produce interleukin-2, indicative of a polyfunctional phenotype as found in controlled chronic viral infections. Our data support the concept that clonally expanded EBNA1-specific CD4+ T cells potentially contribute to the development of MS by cross-recognition of myelin antigens.
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Cites
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Cited by
Filippi, M., Bar-Or, A., Piehl, F., Preziosa, P., Solari, A., Vukusic, S., & Rocca, M. A. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0041-4 · Cited by 1,562
Molecular mimicry and autoimmunity
Rojas, M., Restrepo-Jiménez, P., Monsalve, D. M., Pacheco, Y., Acosta-Ampudia, Y., Ramírez-Santana, C., Leung, P. S. C., Ansari, A. A., Gershwin, M. E., & Anaya, J.-M. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.10.012 · Cited by 627
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B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers
van Langelaar, J., Rijvers, L., Smolders, J., & van Luijn, M. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00760 · Cited by 319
Epstein–Barr Virus Infection and Multiple Sclerosis: A Review
Ascherio, A., & Munger, K. L. (2010) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-010-9201-3 · Cited by 259
Metadata
- Authors
- Lünemann, J. D., Jelčić, I., Roberts, S., Lutterotti, A., Tackenberg, B., Martin, R., & Münz, C.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-07-28
- Volume
- 205
- Issue
- 8
- Pages
- 1763-1773
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2113624682
- Cited by
- 334
- References
- 30
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2. https://app.cochat.ai/papers/10.1084/jem.20072397
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- Lünemann, J. D., Jelčić, I., Roberts, S., Lutterotti, A., Tackenberg, B., Martin, R., & Münz, C. (2008). EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20072397
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