The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers
Open accessAbstract
Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells. However, the effective use of anti-CD20 treatment now also reveals an important role for B cells in MS patients. The results from this treatment put forward T-cell activation rather than antibody production by B cells as a driving force behind MS. The main question of how their interaction provokes both B and T cells to infiltrate the CNS and cause local pathology remains to be answered. In this review, we highlight key pathogenic events involving B and T cells that most likely contribute to the pathogenesis of MS. These include (1) peripheral escape of B cells from T cell-mediated control, (2) interaction of pathogenic B and T cells in secondary lymph nodes, and (3) reactivation of B and T cells accumulating in the CNS. We will focus on the functional programs of CNS-infiltrating lymphocyte subsets in MS patients and discuss how these are defined by mechanisms such as antigen presentation, co-stimulation and cytokine production in the periphery. Furthermore, the potential impact of genetic variants and viral triggers on candidate subsets will be debated in the context of MS.
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A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis
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Cited by
Fitzgerald, K. C., Bhargava, P., Smith, M. D., Vizthum, D., Henry-Barron, B., Kornberg, M. D., Cassard, S. D., Kapogiannis, D., Sullivan, P., Baer, D. J., et al. (2022) · eBioMedicine · doi:10.1016/j.ebiom.2022.104124 · Cited by 68
Selective emergence of antibody-secreting cells in the multiple sclerosis brain
Bogers, L., Engelenburg, H. J., Janssen, M., Unger, P.-P. A., Melief, M.-J., Wierenga-Wolf, A. F., Hsiao, C.-C., Mason, M. R. J., Hamann, J., van Langelaar, J., et al. (2023) · eBioMedicine · doi:10.1016/j.ebiom.2023.104465 · Cited by 40
Self-citationRemyelination in multiple sclerosis from the miRNA perspective
Maciak, K., Dziedzic, A., & Saluk, J. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1199313 · Cited by 28
Pathways linking Alzheimer’s disease risk genes expressed highly in microglia
Hodges, A. K., Piers, T. M., Collier, D., Cousins, O., & Pocock, J. M. (2021) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2020.60 · Cited by 21
miR-181a-5p is a potential candidate epigenetic biomarker in multiple sclerosis
Edgünlü, T. G., Yılmaz, Ş. G., Emre, U., Taşdelen, B., Kuru, O., Kutlu, G., & Erdal, M. E. (2022) · Genome · doi:10.1139/gen-2022-0040 · Cited by 14
Metadata
- Authors
- van Langelaar, J., Rijvers, L., Smolders, J., & van Luijn, M. M.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-05-08
- Volume
- 11
- Pages
- 760-760
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3016526220
- Cited by
- 319
- References
- 157
- FWCI
- 23.65
- Type
- journal article
- Language
- en
- Open access
- gold
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- van Langelaar, J., Rijvers, L., Smolders, J., & van Luijn, M. M. (2020). B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.00760
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
