Multiple sclerosis

Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria

Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22366 · Cited by 9,802 · see citing works

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969 · see citing works

The Future of Genetic Studies of Complex Human Diseases

Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355 · see citing works

Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

Polman, C. H., Reingold, S. C., Edan, G., Filippi, M., Hartung, H., Kappos, L., Lublin, F. D., Metz, L. M., McFarland, H. F., O'Connor, P. W., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20703 · Cited by 5,017 · see citing works

Multiple sclerosis

Compston, A., & Coles, A. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61620-7 · Cited by 4,458 · see citing works

A second generation human haplotype map of over 3.1 million SNPs

The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438 · see citing works

Axonal transection in the lesions of multiple sclerosis

Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029 · see citing works

A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis.

Polman, C., O'Connor, P., Havrdová, E., Hutchinson, M., Kappos, L., Miller, D. H., Phillips, J., Lublin, F., Giovannoni, G., Wajgt, A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa044397 · Cited by 3,293 · see citing works

A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis

Lennon, V. A., Wingerchuk, D. M., Kryzer, T. J., Pittock, S. J., Lucchinetti, C. F., Fujihara, K., Nakashima, I., & Weinshenker, B. G. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17551-x · Cited by 3,239 · see citing works

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697 · see citing works

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

Hauser, S. L., Waubant, E., Arnold, D. L., Vollmer, T., Antel, J., Fox, R. J., Bar-Or, A., Panzara, M., Sarkar, N., Agarwal, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706383 · Cited by 2,439 · see citing works

IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel

Lennon, V. A., Kryzer, T. J., Pittock, S. J., Verkman, A. S., & Hinson, S. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050304 · Cited by 2,288 · see citing works

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858 · see citing works

Cortical demyelination and diffuse white matter injury in multiple sclerosis

Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., & Lassmann, H. (2005) · Brain · doi:10.1093/brain/awh641 · Cited by 1,836 · see citing works

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759 · see citing works

Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

(2007) · New England Journal of Medicine · doi:10.1056/nejmoa073493 · Cited by 1,746 · see citing works

Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.

Magliozzi, R., Howell, O., Vora, A., Serafini, B., Nicholas, R., Puopolo, M., Reynolds, R., & Aloisi, F. (2007) · Brain : a journal of neurology · doi:10.1093/brain/awm038 · Cited by 1,468 · see citing works

Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions

Peterson, J. W., Bö, L., Mörk, S., Chang, A., & Trapp, B. D. (2001) · Annals of Neurology · doi:10.1002/ana.1123 · Cited by 1,403 · see citing works

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Wellcome Trust Case Control Consortium, & The Australo-Anglo-American Spondylitis Consortium (TASC) (2007) · Nature Genetics · doi:10.1038/ng.2007.17 · Cited by 1,374 · see citing works

A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

Steinman, L. (2007) · Nature Medicine · doi:10.1038/nm1551 · Cited by 1,367 · see citing works

Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.

Serafini, B., Rosicarelli, B., Magliozzi, R., Stigliano, E., & Aloisi, F. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00049.x · Cited by 1,208 · see citing works

C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206 · see citing works

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

Codarri, L., Gyülvészi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T., & Becher, B. (2011) · Nature Immunology · doi:10.1038/ni.2027 · Cited by 1,191 · see citing works

The Immunopathology of Multiple Sclerosis: An Overview

Lassmann, H., Brück, W., & Lucchinetti, C. F. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00064.x · Cited by 1,182 · see citing works

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G.-X., Dittel, B. N., & Rostami, A. (2011) · Nature Immunology · doi:10.1038/ni.2031 · Cited by 1,071 · see citing works

Environmental risk factors for multiple sclerosis. Part I: The role of infection

Ascherio, A., & Munger, K. L. (2007) · Annals of Neurology · doi:10.1002/ana.21117 · Cited by 1,036 · see citing works

Genetic Heterogeneity in Human Disease

McClellan, J., & King, M.-C. (2010) · Cell · doi:10.1016/j.cell.2010.03.032 · Cited by 981 · see citing works

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

Babbe, H., Roers, A., Waisman, A., Lassmann, H., Goebels, N., Hohlfeld, R., Friese, M., Schröder, R., Deckert, M., Schmidt, S., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.393 · Cited by 951 · see citing works

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

Zheng, Y., Josefowicz, S. Z., Kas, A., Chu, T.-T., Gavin, M. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05563 · Cited by 835 · see citing works

Primary-progressive multiple sclerosis

Miller, D. H., & Leary, S. M. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70243-0 · Cited by 818 · see citing works

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

International MS Genetics Consortium, De Jager, P. L., Jia, X., Wang, J., de Bakker, P. I. W., Ottoboni, L., Aggarwal, N. T., Piccio, L., Raychaudhuri, S., Tran, D., et al. (2009) · Nature Genetics · doi:10.1038/ng.401 · Cited by 800 · see citing works

Evaluation of Patients Treated with Natalizumab for Progressive Multifocal Leukoencephalopathy

Yousry, T. A., Major, E. O., Ryschkewitsch, C. F., Fahle, G. A., Fischer, S. H., Hou, J., Curfman, B. L., Miszkiel, K., Mueller‐Lenke, N., Sánchez, E., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054693 · Cited by 789 · see citing works

Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain

Serafini, B., Rosicarelli, B., Franciotta, D. M., Magliozzi, R., Reynolds, R., Cinque, P. M., Andreoni, L., Trivedi, P., Salvetti, M., Faggioni, A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071030 · Cited by 765 · see citing works

Subpial Demyelination in the Cerebral Cortex of Multiple Sclerosis Patients

Bø, L., Vedeler, C. A., Nyland, H. I., Trapp, B. D., & Mørk, S. J. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.7.723 · Cited by 757 · see citing works

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

Magliozzi, R., Howell, O. W., Reeves, C., Roncaroli, F., Nicholas, R., Serafini, B., Aloisi, F., & Reynolds, R. (2010) · Annals of Neurology · doi:10.1002/ana.22230 · Cited by 747 · see citing works

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells

Koenen, H. J. P. M., Smeets, R. L., Vink, P. M., van Rijssen, E., Boots, A. M. H., & Joosten, I. (2008) · Blood · doi:10.1182/blood-2008-01-133967 · Cited by 735 · see citing works

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724 · see citing works

Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors

Ascherio, A., & Munger, K. L. (2007) · Annals of Neurology · doi:10.1002/ana.21141 · Cited by 714 · see citing works

Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells

Anderson, A. C., Anderson, D. E., Bregoli, L., Hastings, W. D., Kassam, N., Lei, C., Chandwaskar, R., Kármán, J., Su, E. W., Hirashima, M., et al. (2007) · Science · doi:10.1126/science.1148536 · Cited by 703 · see citing works

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis

McMahon, E. J., Bailey, S. L., Castenada, C. V., Waldner, H., & Miller, S. D. (2005) · Nature Medicine · doi:10.1038/nm1202 · Cited by 694 · see citing works

Control of TH17 cells occurs in the small intestine

Esplugues, E., Huber, S., Gagliani, N., Hauser, A. E., Town, T., Wan, Y. Y., O’Connor, W., Rongvaux, A., van Rooijen, N., Haberman, A. M., et al. (2011) · Nature · doi:10.1038/nature10228 · Cited by 653 · see citing works

Pervasive Sharing of Genetic Effects in Autoimmune Disease

Cotsapas, C., Voight, B. F., Rossin, E., Lage, K., Neale, B. M., Wallace, C., Abecasis, G. R., Barrett, J. C., Behrens, T., Cho, J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002254 · Cited by 606 · see citing works

Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions

Joller, N., Hafler, J. P., Brynedal, B., Kassam, N., Spoerl, S., Levin, S. D., Sharpe, A. H., & Kuchroo, V. K. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003081 · Cited by 583 · see citing works

Detecting shared pathogenesis from the shared genetics of immune-related diseases

Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551 · see citing works

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) (2009) · Nature Genetics · doi:10.1038/ng.396 · Cited by 550 · see citing works

The role of nitric oxide in multiple sclerosis

Smith, K. J., & Lassmann, H. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00102-3 · Cited by 531 · see citing works

Age at disability milestones in multiple sclerosis

Confavreux, C., & Vukusic, S. (2006) · Brain · doi:10.1093/brain/awh714 · Cited by 527 · see citing works

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

Dominguez-Villar, M., Baecher-Allan, C. M., & Hafler, D. A. (2011) · Nature Medicine · doi:10.1038/nm.2389 · Cited by 526 · see citing works

Infectious mononucleosis and risk for multiple sclerosis: A meta‐analysis

Thacker, E. L., Mirzaei, F., & Ascherio, A. (2006) · Annals of Neurology · doi:10.1002/ana.20820 · Cited by 517 · see citing works

IL-17–producing human peripheral regulatory T cells retain suppressive function

Bériou, G., Costantino, C. M., Ashley, C. W., Yang, L., Kuchroo, V. K., Baecher‐Allan, C., & Hafler, D. A. (2009) · Blood · doi:10.1182/blood-2008-10-183251 · Cited by 482 · see citing works

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Baranzini, S. E., Wang, J., Gibson, R. A., Galwey, N., Naegelin, Y., Barkhof, F., Radue, E.-W., Lindberg, R. L. P., Uitdehaag, B. M. G., Johnson, M. R., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddn388 · Cited by 476 · see citing works

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis

Haas, J., Hug, A., Viehöver, A., Fritzsching, B., Falk, C. S., Filser, A., Vetter, T., Milkova, L., Korporal, M., Fritz, B., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526065 · Cited by 450 · see citing works

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology

Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Constortium, I. I. B. D. G., Cotsapas, C., & Daly, M. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001273 · Cited by 438 · see citing works

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

McClymont, S. A., Putnam, A. L., Lee, M. R., Esensten, J. H., Liu, W., Hulme, M. A., Hoffmüller, U., Baron, U., Olek, S., Bluestone, J. A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003099 · Cited by 428 · see citing works

Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

O’Connor, K. C., McLaughlin, K. A., Jager, P. L. D., Chitnis, T., Bettelli, E., Xu, C., Robinson, W. H., Cherry, S. V., Bar‐Or, A., Banwell, B., et al. (2007) · Nature Medicine · doi:10.1038/nm1488 · Cited by 419 · see citing works

Unravelling the pathogenesis of myasthenia gravis

Vincent, A. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri916 · Cited by 416 · see citing works

The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis

van Noort, J. M., van Sechel, A. C., Bajramovic, J. J., Ouagmiri, M. E., Polman, C. H., Lassmann, H., & Ravid, R. (1995) · Nature · doi:10.1038/375798a0 · Cited by 402 · see citing works

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

Baranzini, S. E., Galwey, N. W., Wang, J., Khankhanian, P., Lindberg, R., Pelletier, D., Wu, W., Uitdehaag, B. M. J., Kappos, L., GeneMSA Consortium, et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp120 · Cited by 383 · see citing works

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

Campbell, G. R., Ziabreva, I., Reeve, A. K., Krishnan, K. J., Reynolds, R., Howell, O., Lassmann, H., Turnbull, D. M., & Mahad, D. (2011) · Annals of Neurology · doi:10.1002/ana.22109 · Cited by 379 · see citing works

Decreased FOXP3 levels in multiple sclerosis patients

Huan, J., Culbertson, N. E., Spencer, L., Bartholomew, R. M., Burrows, G. G., Chou, Y. K., BOURDETTE, D. N., Ziegler, S. F., Offner, H., & Vandenbark, A. A. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20522 · Cited by 369 · see citing works

Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab

Gunnarsson, M., Malmeström, C., Axelsson, M., Sundström, P., Dahle, C., Vrethem, M., Olsson, T. P., Piehl, F., Norgren, N., Rosengren, L., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22247 · Cited by 346 · see citing works

Pathway analysis of seven common diseases assessed by genome-wide association

Torkamani, A., Topol, E. J., & Schork, N. J. (2008) · Genomics · doi:10.1016/j.ygeno.2008.07.011 · Cited by 345 · see citing works

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

Lünemann, J. D., Jelčić, I., Roberts, S., Lutterotti, A., Tackenberg, B., Martinꝉ, R., & Münz, C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072397 · Cited by 337 · see citing works

Multiple sclerosis

Hafler, D. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21357 · Cited by 336 · see citing works

Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain.

Willis, S., Stadelmann, C., Rodig, S., Caron, T. J., Gattenloehner, S., Mallozzi, S. S., Roughan, J. E., Almendinger, S. E., Blewett, M. M., Brück, W., et al. (2009) · Brain : a journal of neurology · doi:10.1093/brain/awp200 · Cited by 304 · see citing works

A High-Density Screen for Linkage in Multiple Sclerosis

(2005) · The American Journal of Human Genetics · doi:10.1086/444547 · Cited by 297 · see citing works

Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis

Booss, J., Esiri, M. M., Tourtellotte, W. W., & Mason, D. Y. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90201-0 · Cited by 294 · see citing works

Human memory FOXP3 + Tregs secrete IL-17 ex vivo and constitutively express the T H 17 lineage-specific transcription factor RORγt

Ayyoub, M., Deknuydt, F., Raimbaud, I., Dousset, C., Leveque, L., Bioley, G., & Valmori, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900621106 · Cited by 293 · see citing works

MR Imaging of Multiple Sclerosis

Filippi, M., & Rocca, M. A. (2011) · Radiology · doi:10.1148/radiol.11101362 · Cited by 280 · see citing works

Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.

Wucherpfennig, K. W., Newcombe, J., Li, H., Keddy, C., Cuzner, M. L., & Hafler, D. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4588 · Cited by 278 · see citing works

Changes in B- and T-Lymphocyte and Chemokine Levels With Rituximab Treatment in Multiple Sclerosis

Piccio, L. M., Naismith, R. T., Trinkaus, K. M., Klein, R. S., Parks, B. J., Lyons, J., & Cross, A. H. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.99 · Cited by 274 · see citing works

Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown

Prineas, J. W., & Graham, J. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100205 · Cited by 265 · see citing works

Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score

Jager, P. L. D., Chibnik, L. B., Cui, J., Reischl, J., Lehr, S., Simon, K. C., Aubin, C., Bauer, D., Heubach, J. F., Sandbrink, R., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70275-3 · Cited by 261 · see citing works

Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methods

Kabat, E. A., Glusman, M., & Knaub, V. (1948) · The American Journal of Medicine · doi:10.1016/s0002-9343(48)90389-1 · Cited by 258 · see citing works

CD226 Gly307Ser association with multiple autoimmune diseases

Hafler, J., Maier, L., Cooper, J. D., Plagnol, V., Hinks, A., Simmonds, M., Stevens, H. E., Walker, N., Healy, B., Howson, J., et al. (2008) · Genes and Immunity · doi:10.1038/gene.2008.82 · Cited by 248 · see citing works

Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

Jakkula, E., Leppä, V., Sulonen, A.-M., Varilo, T., Kallio, S., Kemppinen, A., Purcell, S., Koivisto, K., Tienari, P., Sumelahti, M.-L., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.01.017 · Cited by 245 · see citing works

Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis

Lünemann, J. D. (2006) · Brain · doi:10.1093/brain/awl067 · Cited by 238 · see citing works

Dysregulated T cell expression of TIM3 in multiple sclerosis

Koguchi, K., Anderson, D. E., Yang, L., O’Connor, K. C., Kuchroo, V. K., & Hafler, D. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060210 · Cited by 232 · see citing works

Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis

Lovato, L., Willis, S. N., Rodig, S. J., Caron, T. J., Almendinger, S. E., Howell, O. W., Reynolds, R., O’Connor, K. C., & Hafler, D. A. (2011) · Brain · doi:10.1093/brain/awq350 · Cited by 225 · see citing works

The role of the CD58 locus in multiple sclerosis

Jager, P. L. D., Baecher‐Allan, C., Maier, L. M., Arthur, A. T., Ottoboni, L., Barcellos, L. F., McCauley, J. L., Sawcer, S. J., Goris, A., Saarela, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813310106 · Cited by 198 · see citing works

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Aulchenko, Y. S., Hoppenbrouwers, I. A., Ramagopalan, S. V., Broer, L., Jafari, N., Hillert, J. A., Link, J., Lundström, W., Greiner, E., Sadovnick, A. D., et al. (2008) · Nature Genetics · doi:10.1038/ng.251 · Cited by 194 · see citing works

Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.

Wucherpfennig, K. W., Catz, I., Hausmann, S., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119622 · Cited by 192 · see citing works

Epstein-Barr virus in the multiple sclerosis brain: a controversial issue--report on a focused workshop held in the Centre for Brain Research of the Medical University of Vienna, Austria

Lassmann, H., Niedobitek, G., Aloisi, F., Middeldorp, J. M., & the NeuroproMiSe EBV Working Group (2011) · Brain · doi:10.1093/brain/awr197 · Cited by 190 · see citing works

Age-Dependent B Cell Autoimmunity to a Myelin Surface Antigen in Pediatric Multiple Sclerosis

McLaughlin, K. A., Chitnis, T., Newcombe, J., Franz, B., Kennedy, J., McArdel, S. L., Kühle, J., Kappos, L., Rostasy, K. M., Pohl, D., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801888 · Cited by 189 · see citing works

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

Sanna, S., Pitzalis, M., Zoledziewska, M., Zara, I., Sidore, C., Murru, R., Whalen, M. B., Busonero, F., Maschio, A., Costa, G., et al. (2010) · Nature Genetics · doi:10.1038/ng.584 · Cited by 187 · see citing works

How many genes underlie the occurrence of common complex diseases in the population?

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