Illuminating the silence: understanding the structure and function of small RNAs
Abstract
RNA interference (RNAi) is triggered by double-stranded RNA helices that have been introduced exogenously into cells as small interfering (si)RNAs or that have been produced endogenously from small non-coding RNAs known as microRNAs (miRNAs). RNAi has become a standard experimental tool and its therapeutic potential is being aggressively harnessed. Understanding the structure and function of small RNAs, such as siRNAs and miRNAs, that trigger RNAi has shed light on the RNAi machinery. In particular, it has highlighted the assembly and function of the RNA-induced silencing complex (RISC), and has provided guidelines to efficiently silence genes for biological research and therapeutic applications of RNAi.
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MicroRNAs (miRNAs) are short non-coding RNAs that mediate post-transcriptional gene silencing.
“MicroRNAs (miRNAs) are short (~22 nucleotide) non-coding RNAs that mediate post-transcriptional gene silencing (Filipowicz et al., 2008; Rana, 2007).”
From Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 (2010) · cites this paper as Rana, 2007
Cites
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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Cabral, H., Miyata, K., Osada, K., & Kataoka, K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00199 · Cited by 1,309 · see citing works
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Ragni, E., Montemurro, T., Montelatici, E., Lavazza, C., Viganò, M., Rebulla, P., Giordano, R., & Lazzari, L. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.04.002 · Cited by 48 · see citing works
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- Authors
- Rana, T. M.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-01
- Volume
- 8
- Issue
- 1
- Pages
- 23-36
- ISSN
- 1471-0072
- 1471-0080
- Cited by
- 837
- References
- 3
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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