The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
Open accessAbstract
MicroRNAs (miRNAs) are implicated in the differentiation and function of many cell types. We provide genetic and in vivo evidence that the two RNaseIII enzymes, Drosha and Dicer, do indeed function in the same pathway. These have previously been shown to mediate the stepwise maturation of miRNAs (Lee, Y., C. Ahn, J. Han, H. Choi, J. Kim, J. Yim, J. Lee, P. Provost, O. Radmark, S. Kim, and V.N. Kim. 2003. Nature. 425:415–419), and genetic ablation of either within the T cell compartment, or specifically within Foxp3+ regulatory T (T reg) cells, results in identical phenotypes. We found that miRNA biogenesis is indispensable for the function of T reg cells. Specific deletion of either Drosha or Dicer phenocopies mice lacking a functional Foxp3 gene or Foxp3+ cells, whereas deletion throughout the T cell compartment also results in spontaneous inflammatory disease, but later in life. Thus, miRNA-dependent regulation is critical for preventing spontaneous inflammation and autoimmunity.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Oncomirs—MicroRNAs with a role in cancer
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Self-citationThe nuclear RNase III Drosha initiates microRNA processing
Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., et al. (2003) · Nature · doi:10.1038/nature01957 · Cited by 5,114
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The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,088
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Self-citationTRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
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Cited by
Regulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866
Self-citationPlasticity of CD4+ T Cell Lineage Differentiation
Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551
Self-citationPhysiological and pathological roles for microRNAs in the immune system
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature Reviews Immunology · doi:10.1038/nri2708 · Cited by 1,378
MicroRNA Control in the Immune System: Basic Principles
Xiao, C., & Rajewsky, K. (2009) · Cell · doi:10.1016/j.cell.2008.12.027 · Cited by 1,018
MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development
O'Connell, R. M., Kahn, D., Gibson, W. S. J., Round, J. L., Scholz, R. L., Chaudhuri, A. A., Kahn, M. E., Rao, D. S., & Baltimore, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.009 · Cited by 889
Metadata
- Authors
- Chong, M. M. W., Rasmussen, J. P., Rudensky, A. Y., & Littman, D. R.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-08-25
- Volume
- 205
- Issue
- 9
- Pages
- 2005-2017
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1975336035
- Cited by
- 362
- References
- 46
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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