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Cited by 2,713

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

Lau, Nelson C., Lim, Lee P., Weinstein, Earl G., Bartel, David P.·2001·Science
DOI 10.1126/science.1065062
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Abstract

Two small temporal RNAs (stRNAs), lin-4 and let-7 , control developmental timing in Caenorhabditis elegans . We find that these two regulatory RNAs are members of a large class of 21- to 24-nucleotide noncoding RNAs, called microRNAs (miRNAs). We report on 55 previously unknown miRNAs in C. elegans . The miRNAs have diverse expression patterns during development: a let-7 paralog is temporally coexpressed with let-7 ; miRNAs encoded in a single genomic cluster are coexpressed during embryogenesis; and still other miRNAs are expressed constitutively throughout development. Potential orthologs of several of these miRNA genes were identified in Drosophila and human genomes. The abundance of these tiny RNAs, their expression patterns, and their evolutionary conservation imply that, as a class, miRNAs have broad regulatory functions in animals.

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Crossref · 10.1126/science.1065062

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3 of 3 references verified0 citation errors · 0 not checkable

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  • Some miRNAs are organized in the genome as clusters sometimes separated by intervals as short as a few nucleotides.

    “Some miRNAs are organized in the genome as clusters sometimes separated by intervals as short as a few nucleotides (Lagos-Quintana et al. 2001;Lau et al. 2001).”

    From A microRNA array reveals extensive regulation of microRNAs during brain development (2003) · cites this paper as Lau et al. 2001

  • Many miRNAs, often with highly conserved sequences, are present in the genomes of C. elegans, Drosophila, mice, and humans.

    “Many miRNAs, often with highly conserved sequences, are present in the genomes of Caenorhabditis elegans, Drosophila, mice, and humans (Lagos-Quintana et al. 2001, 2002;Lau et al. 2001;Lee and Ambros 2001;Mourelatos et al. 2002;Dostie et al. 2003).”

    From A microRNA array reveals extensive regulation of microRNAs during brain development (2003) · cites this paper as Lau et al. 2001

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Authors
Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P.
Affiliations
Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2001-10-26
Volume
294
Issue
5543
Pages
858-862
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1065062
Cited by
2,713
References
3
Language
en

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