The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis
Open accessAbstract
Mouse breast regression protein 39 (BRP-39; Chi3l1) and its human homologue YKL-40 are chitinase-like proteins that lack chitinase activity. Although YKL-40 is expressed in exaggerated quantities and correlates with disease activity in asthma and many other disorders, the biological properties of BRP-39/YKL-40 have only been rudimentarily defined. We describe the generation and characterization of BRP-39−/− mice, YKL-40 transgenic mice, and mice that lack BRP-39 and produce YKL-40 only in their pulmonary epithelium. Studies of these mice demonstrated that BRP-39−/− animals have markedly diminished antigen-induced Th2 responses and that epithelial YKL-40 rescues the Th2 responses in these animals. The ability of interleukin13 to induce tissue inflammation and fibrosis was also markedly diminished in the absence of BRP-39. Mechanistic investigations demonstrated that BRP-39 and YKL-40 play an essential role in antigen sensitization and immunoglobulin E induction, stimulate dendritic cell accumulation and activation, and induce alternative macrophage activation. These proteins also inhibit inflammatory cell apoptosis/cell death while inhibiting Fas expression, activating protein kinase B/AKT, and inducing Faim 3. These studies establish novel regulatory roles for BRP-39/YKL-40 in the initiation and effector phases of Th2 inflammation and remodeling and suggest that these proteins are therapeutic targets in Th2- and macrophage-mediated disorders.
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Cites
Macrophage activation and polarization
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Self-citationAcidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
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Self-citationChitin induces accumulation in tissue of innate immune cells associated with allergy
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Life and death in peripheral T cells
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Self-citationA Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma
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Macrophages: master regulators of inflammation and fibrosis
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Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury
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Self-citationChitinase-3 like-protein-1 function and its role in diseases
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YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease
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Metadata
- Authors
- Lee, C. G., Hartl, D., Lee, G. R., Koller, B., Matsuura, H., Da Silva, C. A., Sohn, M. H., Cohn, L., Homer, R. J., Kozhich, A. A., Humbles, A., Kearley, J., Coyle, A., Chupp, G., Reed, J., Flavell, R. A., & Elias, J. A.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2009-05-04
- Volume
- 206
- Issue
- 5
- Pages
- 1149-1166
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2160395680
- Cited by
- 434
- References
- 49
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis. https://app.cochat.ai/papers/10.1084/jem.20081271
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- Lee, C. G., Hartl, D., Lee, G. R., Koller, B., Matsuura, H., Da Silva, C. A., Sohn, M. H., Cohn, L., Homer, R. J., Kozhich, A. A., Humbles, A., Kearley, J., Coyle, A., Chupp, G., Reed, J., Flavell, R. A., & Elias, J. A. (2009). Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20081271
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
