The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
Open accessAbstract
Many pathogens that cause human disease infect only humans. To identify the mechanisms of immune protection against these pathogens and also to evaluate promising vaccine candidates, a small animal model would be desirable. We demonstrate that primary T cell responses in mice with reconstituted human immune system components control infection with the oncogenic and persistent Epstein-Barr virus (EBV). These cytotoxic and interferon-γ–producing T cell responses were human leukocyte antigen (HLA) restricted and specific for EBV-derived peptides. In HLA-A2 transgenic animals and similar to human EBV carriers, T cell responses against lytic EBV antigens dominated over recognition of latent EBV antigens. T cell depletion resulted in elevated viral loads and emergence of EBV-associated lymphoproliferative disease. Both loss of CD4+ and CD8+ T cells abolished immune control. Therefore, this mouse model recapitulates features of symptomatic primary EBV infection and generates T cell–mediated immune control that resists oncogenic transformation.
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Cites
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Of Mice and Not Men: Differences between Mouse and Human Immunology
Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822
Cited by
Norelli, M., Camisa, B., Barbiera, G., Falcone, L., Purevdorj, A., Genua, M., Sanvito, F., Ponzoni, M., Doglioni, C., Cristofori, P., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0036-4 · Cited by 1,406
Humanized mouse models for immuno-oncology research
Chuprin, J., Buettner, H., Seedhom, M. O., Greiner, D. L., Keck, J. G., Ishikawa, F., Shultz, L. D., & Brehm, M. A. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00721-2 · Cited by 423
Current advances in humanized mouse models
Ito, R., Takahashi, T., Katano, I., & Ito, M. (2012) · Cellular & Molecular Immunology · doi:10.1038/cmi.2012.2 · Cited by 349
Humanized mice in studying efficacy and mechanisms of PD‐1‐targeted cancer immunotherapy
Wang, M., Yao, L., Cheng, M., Cai, D., Martinek, J., Pan, C., Shi, W., Ma, A., de Vere White, R. W., Airhart, S., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700740r · Cited by 339
Brehm, M. A., Cuthbert, A., Yang, C., Miller, D. M., DiIorio, P., Laning, J., Burzenski, L., Gott, B., Foreman, O., Kavirayani, A., et al. (2010) · Clinical Immunology · doi:10.1016/j.clim.2009.12.008 · Cited by 273
Metadata
- Authors
- Strowig, T., Gurer, C., Ploss, A., Liu, Y.-F., Arrey, F., Sashihara, J., Koo, G., Rice, C. M., Young, J. W., Chadburn, A., Cohen, J. I., & Münz, C.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2009-06-01
- Volume
- 206
- Issue
- 6
- Pages
- 1423-1434
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2038363431
- Cited by
- 300
- References
- 2
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Strowig, T., Gurer, C., Ploss, A., Liu, Y.-F., Arrey, F., Sashihara, J., Koo, G., Rice, C. M., Young, J. W., Chadburn, A., Cohen, J. I., & Münz, C. (2009). Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20081720
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