The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Humanized mice in studying efficacy and mechanisms of PD‐1‐targeted cancer immunotherapy
Open accessAbstract
Establishment of an in vivo small animal model of human tumor and human immune system interaction would enable preclinical investigations into the mechanisms underlying cancer immunotherapy. To this end, nonobese diabetic ( NOD).Cg‐Prkdc scid IL2rg tm1Wjl /Sz (null; NSG) mice were transplanted with human (h)CD34 + hematopoietic progenitor and stem cells, which leads to the development of human hematopoietic and immune systems [humanized NSG (HuNSG)]. HuNSG mice received human leukocyte antigen partially matched tumor implants from patient‐ derived xenografts [PDX; non ‐ small cell lung cancer (NSCLC), sarcoma, bladder cancer, and triple‐negative breast cancer (TNBC)] or from a TNBC cell line‐derived xenograft (CDX). Tumor growth curves were similar in HuNSG compared with nonhuman immune‐engrafted NSG mice. Treatment with pembrolizumab, which targets programmed cell death protein 1, produced significant growth inhibition in both CDX and PDX tumors in HuNSG but not in NSG mice. Finally, inhibition of tumor growth was dependent on hCD8 + T cells, as demonstrated by antibody‐mediated depletion. Thus, tumor‐bearing HuNSG mice may represent an important, new model for preclinical immunotherapy research.—Wang, M., Yao, L.‐C., Cheng, M., Cai, D., Martinek, J., Pan, C.‐X., Shi, W., Ma, A.‐H., De Vere White, R. W., Airhart, S., Liu, E. T., Banchereau, J., Brehm, M. A., Greiner, D. L., Shultz, L. D., Palucka, K., Keck, J. G. Humanized mice in studying efficacy and mechanisms of PD‐1‐targeted cancer immunotherapy. FASEB J. 32,1537 ‐1549 (2018). www.fasebj.org
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Cites
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Self-citationMouse Models for Cancer Immunotherapy Research
Olson, B., Li, Y., Lin, Y., Liu, E. T., & Patnaik, A. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0044 · Cited by 435
Self-citationHumanized mouse models for immuno-oncology research
Chuprin, J., Buettner, H., Seedhom, M. O., Greiner, D. L., Keck, J. G., Ishikawa, F., Shultz, L. D., & Brehm, M. A. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00721-2 · Cited by 423
Self-citationGuillen, K. P., Fujita, M., Butterfield, A. J., Scherer, S. D., Bailey, M. H., Chu, Z., DeRose, Y. S., Zhao, L., Cortes-Sanchez, E., Yang, C.-H., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00337-6 · Cited by 416
Multiplexed drug testing of tumor slices using a microfluidic platform
Horowitz, L. F., Rodriguez, A. D., Dereli-Korkut, Z., Lin, R., Castro, K., Mikheev, A. M., Monnat, R. J., Folch, A., & Rostomily, R. C. (2020) · npj Precision Oncology · doi:10.1038/s41698-020-0117-y · Cited by 88
Metadata
- Authors
- Wang, M., Yao, L., Cheng, M., Cai, D., Martinek, J., Pan, C., Shi, W., Ma, A., de Vere White, R. W., Airhart, S., Liu, E. T., Banchereau, J., Brehm, M. A., Greiner, D. L., Shultz, L. D., Palucka, K., & Keck, J. G.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2018-01-03
- Volume
- 32
- Issue
- 3
- Pages
- 1537-1549
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2768987490
- Cited by
- 339
- References
- 52
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wang, M., Yao, L., Cheng, M., Cai, D., Martinek, J., Pan, C., Shi, W., Ma, A., de Vere White, R. W., Airhart, S., Liu, E. T., Banchereau, J., Brehm, M. A., Greiner, D. L., Shultz, L. D., Palucka, K., & Keck, J. G. (2018). Humanized mice in studying efficacy and mechanisms of PD‐1‐targeted cancer immunotherapy. The FASEB Journal. https://doi.org/10.1096/fj.201700740r
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
