The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation
Open accessAbstract
“Humanized” mouse models created by engraftment of immunodeficient mice with human hematolymphoid cells or tissues are an emerging technology with broad appeal across multiple biomedical disciplines. However, investigators wishing to utilize humanized mice with engrafted functional human immune systems are faced with a myriad of variables to consider. In this study, we analyze HSC engraftment methodologies using three immunodeficient mouse strains harboring the IL2rγnull mutation; NOD-scid IL2rγnull, NOD-Rag1null IL2rγnull, and BALB/c-Rag1null IL2rγnull mice. Strategies compared engraftment of human HSC derived from umbilical cord blood following intravenous injection into adult mice and intracardiac and intrahepatic injection into newborn mice. We observed that newborn recipients exhibited enhanced engraftment as compared to adult recipients. Irrespective of the protocol or age of recipient, both immunodeficient NOD strains support enhanced hematopoietic cell engraftment as compared to the BALB/c strain. Our data define key parameters for establishing humanized mouse models to study human immunity.
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Humanized mouse models for immuno-oncology research
Chuprin, J., Buettner, H., Seedhom, M. O., Greiner, D. L., Keck, J. G., Ishikawa, F., Shultz, L. D., & Brehm, M. A. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00721-2 · Cited by 423
Self-citationCurrent advances in humanized mouse models
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Animal models for HIV/AIDS research
Hatziioannou, T., & Evans, D. T. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2911 · Cited by 340
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Metadata
- Authors
- Brehm, M. A., Cuthbert, A., Yang, C., Miller, D. M., DiIorio, P., Laning, J., Burzenski, L., Gott, B., Foreman, O., Kavirayani, A., Herlihy, M., Rossini, A. A., Shultz, L. D., & Greiner, D. L.
- Venue
- Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 135
- Issue
- 1
- Pages
- 84-98
- ISSN
- 1521-6616 (ISSN-L)
- OpenAlex
- W1984295407
- Cited by
- 273
- References
- 37
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Brehm, M. A., Cuthbert, A., Yang, C., Miller, D. M., DiIorio, P., Laning, J., Burzenski, L., Gott, B., Foreman, O., Kavirayani, A., Herlihy, M., Rossini, A. A., Shultz, L. D., & Greiner, D. L. (2010). Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation. Clinical Immunology. https://doi.org/10.1016/j.clim.2009.12.008
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