The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia
Open accessAbstract
The function of microRNAs (miRNAs) in hematopoietic stem cells (HSCs), committed progenitors, and leukemia stem cells (LSCs) is poorly understood. We show that miR-29a is highly expressed in HSC and down-regulated in hematopoietic progenitors. Ectopic expression of miR-29a in mouse HSC/progenitors results in acquisition of self-renewal capacity by myeloid progenitors, biased myeloid differentiation, and the development of a myeloproliferative disorder that progresses to acute myeloid leukemia (AML). miR-29a promotes progenitor proliferation by expediting G1 to S/G2 cell cycle transitions. miR-29a is overexpressed in human AML and, like human LSC, miR-29a-expressing myeloid progenitors serially transplant AML. Our data indicate that miR-29a regulates early hematopoiesis and suggest that miR-29a initiates AML by converting myeloid progenitors into self-renewing LSC.
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Cites
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InfluentialA clonogenic common myeloid progenitor that gives rise to all myeloid lineages
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Self-citationGranulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
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Cited by
MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
Kasinski, A. L., & Slack, F. J. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3166 · Cited by 936
MicroRNAs as regulatory elements in immune system logic
Mehta, A., & Baltimore, D. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.40 · Cited by 704
Feldman, A. L., Dogan, A., Smith, D. I., Law, M. E., Ansell, S. M., Johnson, S. H., Porcher, J. C., Özsan, N., Wieben, E. D., Eckloff, B. W., et al. (2011) · Blood · doi:10.1182/blood-2010-08-303305 · Cited by 297
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Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion
Lechman, E. R., Gentner, B., van Galen, P., Giustacchini, A., Saini, M., Boccalatte, F. E., Hiramatsu, H., Restuccia, U., Bachi, A., Voisin, V., et al. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.09.001 · Cited by 208
Metadata
- Authors
- Han, Y.-C., Park, C. Y., Bhagat, G., Zhang, J., Wang, Y., Fan, J.-B., Liu, M., Zou, Y., Weissman, I. L., & Gu, H.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2010-03-08
- Volume
- 207
- Issue
- 3
- Pages
- 475-489
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2149784145
- Cited by
- 290
- References
- 7
- FWCI
- 18.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Han, Y.-C., Park, C. Y., Bhagat, G., Zhang, J., Wang, Y., Fan, J.-B., Liu, M., Zou, Y., Weissman, I. L., & Gu, H. (2010). microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20090831
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