MicroRNAs as regulatory elements in immune system logic

Mehta, Arnav; Baltimore, David

doi:10.1038/nri.2016.40

Cited by 704MicroRNA in disease regulationT-cell and B-cell ImmunologyPlant Molecular Biology Research

MicroRNAs as regulatory elements in immune system logic

Mehta, Arnav, Baltimore, David·2016·Nature Reviews Immunology

DOI 10.1038/nri.2016.40

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Abstract

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate decisions. They act by negatively regulating the expression of key immune development genes, thus contributing important logic elements to the regulatory circuitry. Deletion studies have made it increasingly apparent that they confer robustness to immune cell development, especially under conditions of environmental stress such as infectious challenge and ageing. Aberrant expression of certain miRNAs can lead to pathological consequences, such as autoimmunity and haematological cancers. In this Review, we discuss the mechanisms by which several miRNAs influence immune development and buffer normal haematopoietic output, first at the level of haematopoietic stem cells, then in innate and adaptive immune cells. We then discuss the pathological consequences of dysregulation of these miRNAs.

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Macrophages and granulocytes are professional phagocytes and each may be a cellular target for microRNAs.
“Both macrophages and granulocytes are called professional phagocytes, and each may be a cellular target for microRNAs, but only macrophages are considered as appropriate for potential experimental transfection [53].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [53]
Only macrophages are considered appropriate for potential experimental transfection among professional phagocytes.
“Both macrophages and granulocytes are called professional phagocytes, and each may be a cellular target for microRNAs, but only macrophages are considered as appropriate for potential experimental transfection [53].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [53]

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MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis
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MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection
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The Interaction Between Two Worlds: MicroRNAs and Toll-Like Receptors
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miR-221-3p Drives the Shift of M2-Macrophages to a Pro-Inflammatory Function by Suppressing JAK3/STAT3 Activation
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Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells
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Evolutionary Parasitology
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The Airway Epithelium—A Central Player in Asthma Pathogenesis
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The Emerging Roles of miR-125b in Cancers
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miRNA-124 in Immune System and Immune Disorders
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Clinical significance of miRNAs in autoimmunity
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Neuroinflammation in preterm babies and autism spectrum disorders
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Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients
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MicroRNAs, Regulatory Messengers Inside and Outside Cancer Cells
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The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases
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Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155
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miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis
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Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer
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Antitumor immunity is defective in T cell–specific microRNA-155–deficient mice and is rescued by immune checkpoint blockade
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Authors: Mehta, A., & Baltimore, D.
Affiliations: California Institute of Technology (US)
Corresponding author: Mehta, Arnav
Baltimore, David
ORCID: Mehta, Arnav
Baltimore, David
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2016-04-28
Volume: 16
Issue: 5
Pages: 279-294
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri.2016.40
OpenAlex: W2343186061
Cited by: 704
References: 259
Citations by year: 2026: 29 · 2025: 55 · 2024: 43 · 2023: 52 · 2022: 84 · 2021: 122 · 2020: 100 · 2019: 67 · 2018: 79 · 2017: 58 · 2016: 14
FWCI: 6.67
Type: journal article
Language: en
Update notices: erratum (2016-05-23)
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Cancer Institute (F30CA183220)
National Institute of Allergy and Infectious Diseases (R01AI079243)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: microRNA, post-transcriptional regulation, immune cell development, hematopoiesis, cell fate determination, hematopoietic stem cells, innate immune cells, adaptive immune cells, autoimmunity, hematologic cancer, aging, infection
MeSH terms: Animals, Cell Differentiation, Disease Susceptibility, Gene Expression Regulation, Hematopoietic Stem Cells, Homeostasis, Humans, Immune System, Immunity, Innate, Autoimmunity, MicroRNAs, Adaptive Immunity, Immunomodulation

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MicroRNAs as regulatory elements in immune system logic

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