The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing
Open accessAbstract
The genetics of peripheral T-cell lymphomas are poorly understood. The most well-characterized abnormalities are translocations involving ALK, occurring in approximately half of anaplastic large cell lymphomas (ALCLs). To gain insight into the genetics of ALCLs lacking ALK translocations, we combined mate-pair DNA library construction, massively parallel (“Next Generation”) sequencing, and a novel bioinformatic algorithm. We identified a balanced translocation disrupting the DUSP22 phosphatase gene on 6p25.3 and adjoining the FRA7H fragile site on 7q32.3 in a systemic ALK-negative ALCL. Using fluorescence in situ hybridization, we demonstrated that the t(6;7)(p25.3;q32.3) was recurrent in ALK-negative ALCLs. Furthermore, t(6;7)(p25.3;q32.3) was associated with down-regulation of DUSP22 and up-regulation of MIR29 microRNAs on 7q32.3. These findings represent the first recurrent translocation reported in ALK-negative ALCL and highlight the utility of massively parallel genomic sequencing to discover novel translocations in lymphoma and other cancers.
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Metadata
- Authors
- Feldman, A. L., Dogan, A., Smith, D. I., Law, M. E., Ansell, S. M., Johnson, S. H., Porcher, J. C., Özsan, N., Wieben, E. D., Eckloff, B. W., & Vasmatzis, G.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-01-20
- Volume
- 117
- Issue
- 3
- Pages
- 915-919
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1988080979
- Cited by
- 297
- References
- 22
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. https://app.cochat.ai/papers/10.1182/blood-2010-08-303305
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- Feldman, A. L., Dogan, A., Smith, D. I., Law, M. E., Ansell, S. M., Johnson, S. H., Porcher, J. C., Özsan, N., Wieben, E. D., Eckloff, B. W., & Vasmatzis, G. (2011). Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. Blood. https://doi.org/10.1182/blood-2010-08-303305
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