The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates
Open accessAbstract
Streptococcus agalactiae (group B streptococcus; GBS) is a normal constituent of the intestinal microflora and the major cause of human neonatal meningitis. A single clone, GBS ST-17, is strongly associated with a deadly form of the infection called late-onset disease (LOD), which is characterized by meningitis in infants after the first week of life. The pathophysiology of LOD remains poorly understood, but our epidemiological and histopathological results point to an oral route of infection. Here, we identify a novel ST-17–specific surface-anchored protein that we call hypervirulent GBS adhesin (HvgA), and demonstrate that its expression is required for GBS hypervirulence. GBS strains that express HvgA adhered more efficiently to intestinal epithelial cells, choroid plexus epithelial cells, and microvascular endothelial cells that constitute the blood–brain barrier (BBB), than did strains that do not express HvgA. Heterologous expression of HvgA in nonadhesive bacteria conferred the ability to adhere to intestinal barrier and BBB-constituting cells. In orally inoculated mice, HvgA was required for intestinal colonization and translocation across the intestinal barrier and the BBB, leading to meningitis. In conclusion, HvgA is a critical virulence trait of GBS in the neonatal context and stands as a promising target for the development of novel diagnostic and antibacterial strategies.
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Cites
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Cited by
Dando, S. J., Mackay-Sim, A., Norton, R., Currie, B. J., St. John, J. A., Ekberg, J. A. K., Batzloff, M., Ulett, G. C., & Beacham, I. R. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00118-13 · Cited by 428
Nanduri, S. A., Petit, S., Smelser, C., Apostol, M., Alden, N. B., Harrison, L. H., Lynfield, R., Vagnone, P. S., Burzlaff, K., Spina, N. L., et al. (2019) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2018.4826 · Cited by 389
Community-acquired bacterial meningitis
van de Beek, D., Brouwer, M., Hasbun, R., Koedel, U., Whitney, C. G., & Wijdicks, E. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.74 · Cited by 312
A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers
Coureuil, M., Lécuyer, H., Bourdoulous, S., & Nassif, X. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.178 · Cited by 299
Host–pathogen interactions in bacterial meningitis.
Doran, K. S., Fulde, M., Gratz, N., Kim, B. J., Nau, R., Prasadarao, N., Schubert-Unkmeir, A., Tuomanen, E. I., & Valentin-Weigand, P. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1531-z · Cited by 208
Metadata
- Authors
- Tazi, A., Disson, O., Bellais, S., Bouaboud, A., Dmytruk, N., Dramsi, S., Mistou, M.-Y., Khun, H., Mechler, C., Tardieux, I., Trieu-Cuot, P., Lecuit, M., & Poyart, C.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2010-10-18
- Volume
- 207
- Issue
- 11
- Pages
- 2313-2322
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2029531605
- Cited by
- 310
- References
- 28
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tazi, A., Disson, O., Bellais, S., Bouaboud, A., Dmytruk, N., Dramsi, S., Mistou, M.-Y., Khun, H., Mechler, C., Tardieux, I., Trieu-Cuot, P., Lecuit, M., & Poyart, C. (2010). The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20092594
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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