The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection
Open accessAbstract
Resistance to Mycobacterium tuberculosis requires the host to restrict bacterial replication while preventing an over-exuberant inflammatory response. Interferon (IFN) γ is crucial for activating macrophages and also regulates tissue inflammation. We dissociate these two functions and show that IFN-γ−/− memory CD4+ T cells retain their antimicrobial activity but are unable to suppress inflammation. IFN-γ inhibits CD4+ T cell production of IL-17, which regulates neutrophil recruitment. In addition, IFN-γ directly inhibits pathogenic neutrophil accumulation in the infected lung and impairs neutrophil survival. Regulation of neutrophils is important because their accumulation is detrimental to the host. We suggest that neutrophilia during tuberculosis indicates failed Th1 immunity or loss of IFN-γ responsiveness. These results establish an important antiinflammatory role for IFN-γ in host protection against tuberculosis.
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Citations
Cites
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Berry, M. P. R., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Banchereau, R., Skinner, J., Wilkinson, R. J., et al. (2010) · Nature · doi:10.1038/nature09247 · Cited by 1,898
Identification of nitric oxide synthase as a protective locus against tuberculosis
MacMicking, J. D., North, R. J., LaCourse, R., Mudgett, J. S., Shah, S. K., & Nathan, C. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5243 · Cited by 1,180
Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent
Wilson, M. S., Madala, S. K., Ramalingam, T. R., Gochuico, B. R., Rosas, I. O., Cheever, A. W., & Wynn, T. A. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20092121 · Cited by 730
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47
MacMicking, J. D., Taylor, G. A., & McKinney, J. D. (2003) · Science · doi:10.1126/science.1088063 · Cited by 685 · cited 1×
“IFN- is also an essential component of the human immune response to tuberculosis, although its mechanism of action may differ from that defined in mice (Jouanguy et al., 1996, 1997; MacMicking et al., 1997, 2003; Madariaga et al., 1998).”
BackgroundIL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men
Jouanguy, E., Döffinger, R., Dupuis, S., Pallier, A., Altare, F., & Casanova, J.-L. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80055-7 · Cited by 331
McLoughlin, R. M., Witowski, J., Robson, R. L., Wilkinson, T. S., Hurst, S. M., Williams, A. S., Williams, J. D., Rose-John, S., Jones, S. A., & Topley, N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17129 · Cited by 281
Cited by
Autophagy balances inflammation in innate immunity
Deretic, V., & Levine, B. (2018) · Autophagy · doi:10.1080/15548627.2017.1402992 · Cited by 563
Mishra, B. B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., & Sassetti, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2474 · Cited by 571
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation
Castillo, E. F., Dekonenko, A., Arko-Mensah, J., Mandell, M. A., Dupont, N., Jiang, S., Delgado-Vargas, M., Timmins, G. S., Bhattacharya, D., Yang, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210500109 · Cited by 454
Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
Bell, L. C. K., & Noursadeghi, M. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.128 · Cited by 389
Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection
Kimmey, J. M., Huynh, J. P., Weiss, L. A., Park, S., Kambal, A., Debnath, J., Virgin, H. W., & Stallings, C. L. (2015) · Nature · doi:10.1038/nature16451 · Cited by 382
Metadata
- Authors
- Nandi, B., & Behar, S. M.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2011-10-03
- Volume
- 208
- Issue
- 11
- Pages
- 2251-2262
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2145457161
- Cited by
- 374
- References
- 6
- FWCI
- 16.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nandi, B., & Behar, S. M. (2011). Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20110919
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
