Autophagy balances inflammation in innate immunity

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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A role for mitochondria in nlrp3 inflammasome activation

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The Inflammasomes

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

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Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

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Mechanisms and Functions of Inflammasomes

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Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

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Autophagy in infection, inflammation and immunity

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An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

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A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

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Phosphorylation of the Autophagy Receptor Optineurin Restricts <i>Salmonella</i> Growth

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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

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Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

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Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

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Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β

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Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

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Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

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The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

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Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

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Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

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Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

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Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

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The Phagosome Proteome

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TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

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The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

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Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

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Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

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Autophagy Links Inflammasomes to Atherosclerotic Progression

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DAP‐kinase‐mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl‐XL and induction of autophagy

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The ubiquitin ligase parkin mediates resistance to intracellular pathogens

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Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

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The Atg5–Atg12 conjugate associates with innate antiviral immune responses

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Image-based genome-wide siRNA screen identifies selective autophagy factors

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TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

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Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

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Autophagy genes in immunity

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Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

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Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

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Galectin-3, a marker for vacuole lysis by invasive pathogens

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Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

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Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

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Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

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Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection

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TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

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Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses

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Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

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VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

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Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

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TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

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Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy

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TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

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Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

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Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy

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Self and Nonself: How Autophagy Targets Mitochondria and Bacteria

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Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

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Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells.

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The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense

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Fanconi Anemia Proteins Function in Mitophagy and Immunity

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IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

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Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

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LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB

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The Diabetes Susceptibility Gene Clec16a Regulates Mitophagy

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Human TBK1: A Gatekeeper of Neuroinflammation

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Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

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PLA2G16 represents a switch between entry and clearance of Picornaviridae

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The protein SdhA maintains the integrity of the Legionella -containing vacuole

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Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

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TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

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