The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2
Open accessAbstract
The co-stimulators ICOS (inducible T cell co-stimulator) and CD28 are both important for T follicular helper (TFH) cells, yet their individual contributions are unclear. Here, we show that each molecule plays an exclusive role at different stages of TFH cell development. While CD28 regulated early expression of the master transcription factor Bcl-6, ICOS co-stimulation was essential to maintain the phenotype by regulating the novel TFH transcription factor Klf2 via Foxo1. Klf2 directly binds to Cxcr5, Ccr7, Psgl-1, and S1pr1, and low levels of Klf2 were essential to maintain this typical TFH homing receptor pattern. Blocking ICOS resulted in relocation of fully developed TFH cells back to the T cell zone and reversion of their phenotype to non-TFH effector cells, which ultimately resulted in breakdown of the germinal center response. Our study describes for the first time the exclusive role of ICOS and its downstream signaling in the maintenance of TFH cells by controlling their anatomical localization in the B cell follicle.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature · doi:10.1038/nature04606 · Cited by 1,189
Molecular programming of B cell memory
McHeyzer-Williams, M., Okitsu, S., Wang, N., & McHeyzer-Williams, L. (2012) · Nature Reviews Immunology · doi:10.1038/nri3128 · Cited by 449
Controlled gene expression in primary Lgr5 organoid cultures
Koo, B.-K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., van Es, J. H., & Clevers, H. (2012) · Nature Methods · doi:10.1038/nmeth.1802 · Cited by 320
Cited by
T follicular helper cell biology: a decade of discovery and diseases
Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591
Vinuesa, C. G., Linterman, M. A., Yu, D., & MacLennan, I. C. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055605 · Cited by 1,141
Dendritic Cell Regulation of T Helper Cells
Yin, X., Chen, S., & Eisenbarth, S. C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-025146 · Cited by 447
BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms
Hatzi, K., Nance, J. P., Kroenke, M. A., Bothwell, M., Haddad, E. K., Melnick, A., & Crotty, S. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141380 · Cited by 261
RHOA G17V induces t follicular helper cell specification and promotes lymphomagenesis
Cortes, J. R., Ambesi-Impiombato, A., Couronné, L., Quinn, S. A., Kim, C. S., da Silva Almeida, A. C., West, Z., Belver, L., Martin, M. S., Scourzic, L., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.001 · Cited by 207
Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)
Choi, J., & Crotty, S. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.02.002 · Cited by 190
Herati, R. S., Muselman, A., Vella, L., Bengsch, B., Parkhouse, K., Del Alcazar, D., Kotzin, J., Doyle, S. A., Tebas, P., Hensley, S. E., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aag2152 · Cited by 167
RHO Family GTPases in the Biology of Lymphoma
Voena, C., & Chiarle, R. (2019) · Cells · doi:10.3390/cells8070646 · Cited by 35
Understanding CD4+ T cells in autoimmune bullous diseases
Lee, A. Y., Kim, T., & Kim, J. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1161927 · Cited by 13
Metadata
- Authors
- Weber, J. P., Fuhrmann, F., Feist, R. K., Lahmann, A., Al Baz, M. S., Gentz, L.-J., Vu Van, D., Mages, H. W., Haftmann, C., Riedel, R., Grün, J. R., Schuh, W., Kroczek, R. A., Radbruch, A., Mashreghi, M.-F., & Hutloff, A.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2015-02-02
- Volume
- 212
- Issue
- 2
- Pages
- 217-233
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2162068902
- Cited by
- 295
- References
- 3
- FWCI
- 11.54
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
