The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Androgen signaling negatively controls group 2 innate lymphoid cells
Open accessAbstract
Prevalence of asthma is higher in women than in men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) are key regulators of type 2 inflammatory responses. Here, we show that ILC2 development is greatly influenced by male sex hormones. Male mice have reduced numbers of ILC2 progenitors (ILC2Ps) and mature ILC2s in peripheral tissues compared with females. In consequence, males exhibit reduced susceptibility to allergic airway inflammation in response to environmental allergens and less severe IL-33–driven lung inflammation, correlating with an impaired expansion of lung ILC2s. Importantly, orchiectomy, but not ovariectomy, abolishes the sex differences in ILC2 development and restores IL-33–mediated lung inflammation. ILC2Ps express the androgen receptor (AR), and AR signaling inhibits their differentiation into mature ILC2s. Finally, we show that hematopoietic AR expression limits IL-33–driven lung inflammation through a cell-intrinsic inhibition of ILC2 expansion. Thus, androgens play a crucial protective role in type 2 airway inflammation by negatively regulating ILC2 homeostasis, thereby limiting their capacity to expand locally in response to IL-33.
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Cites
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Cited by
Influence of Androgens on Immunity to Self and Foreign: Effects on Immunity and Cancer
Ben-Batalla, I., Vargas-Delgado, M. E., von Amsberg, G., Janning, M., & Loges, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01184 · Cited by 149
“This enhanced presence of ILC2 cells could be one reason for to the enhanced susceptibility of women to develop asthma (137, 138).”
BackgroundMakowska, K., Nowaczyk, J., Blicharz, L., Waśkiel-Burnat, A., Czuwara, J., Olszewska, M., & Rudnicka, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010781 · Cited by 63
Metadata
- Authors
- Laffont, S., Blanquart, E., Savignac, M., Cénac, C., Laverny, G., Metzger, D., Girard, J.-P., Belz, G. T., Pelletier, L., Seillet, C., & Guéry, J.-C.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2017-05-08
- Volume
- 214
- Issue
- 6
- Pages
- 1581-1592
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2612414758
- Cited by
- 282
- References
- 38
- FWCI
- 10.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Laffont, S., Blanquart, E., Savignac, M., Cénac, C., Laverny, G., Metzger, D., Girard, J.-P., Belz, G. T., Pelletier, L., Seillet, C., & Guéry, J.-C. (2017). Androgen signaling negatively controls group 2 innate lymphoid cells. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20161807
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