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Cited by 125IL-33, ST2, and ILC PathwaysT-cell and B-cell ImmunologyMast cells and histamine

Development and differentiation of early innate lymphoid progenitors

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Harly, Christelle, Cam, Maggie, Kaye, Jonathan, Bhandoola, Avinash·2018·Journal of Experimental Medicine
DOI 10.1084/jem.20170832PMC PMC5748853
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Abstract

Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor–successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new candidate regulators of ILC development and clearly defines the stage of requirement of transcription factors key for early ILC development.

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  • The innate lymphoid cell developmental program appears to resemble the intrathymic T-cell program in many respects.

    “So far the innate lymphoid cell developmental program in particular appears to resemble the intrathymic T-cell program in many respects (154–157), enough to raise the question of what makes T-cell precursors wait to activate genes like Tcf7 and Gata3 until they reach the thymus.”

    From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [157]

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Authors
Harly, C., Cam, M., Kaye, J., & Bhandoola, A.
Affiliations
  • National Institutes of Health (US)
  • Cedars-Sinai Medical Center (US)
Corresponding author
Bhandoola, Avinash
ORCID
Venue
Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2017-11-28
Volume
215
Issue
1
Pages
249-262
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.20170832
PMC
PMC5748853
OpenAlex
W2769255069
Cited by
125
References
54
Citations by year
2026: 13 · 2025: 10 · 2024: 14 · 2023: 9 · 2022: 18 · 2021: 9 · 2020: 19 · 2019: 25 · 2018: 8
FWCI
6.44
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Funders
National Cancer Institute
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Keywords
innate lymphoid cells, progenitor cell differentiation, bone marrow, transcription factors, multipotent progenitors
MeSH terms
Animals, Bone Marrow Cells, Cell Differentiation, Immunity, Innate, Mice, Transgenic, Phenotype, Biomarkers, Immunophenotyping, Lymphocyte Subsets, Cytokines, Mice, Knockout, Gene Expression Profiling, GATA3 Transcription Factor, Mice, Lymphoid Progenitor Cells

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