The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Type I interferons in tuberculosis: Foe and occasionally friend
Open accessAbstract
Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection. Type I interferons (IFN) regulate a broad family of genes that either stimulate or inhibit immune function, having both host-protective and detrimental effects, and exhibit well-characterized antiviral activity. Transcriptional studies have uncovered a potential deleterious role for type I IFN in active tuberculosis. Since then, additional studies in human tuberculosis and experimental mouse models of M. tuberculosis infection support the concept that type I IFN promotes both bacterial expansion and disease pathogenesis. More recently, studies in a different setting have suggested a putative protective role for type I IFN. In this study, we discuss the mechanistic and contextual factors that determine the detrimental versus beneficial outcomes of type I IFN induction during M. tuberculosis infection, from human disease to experimental mouse models of tuberculosis.
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Cites
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Cited by
Moreira-Teixeira, L., Tabone, O., Graham, C. M., Singhania, A., Stavropoulos, E., Redford, P. S., Chakravarty, P., Priestnall, S. L., Suarez-Bonnet, A., Herbert, E., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0610-z · Cited by 127
Self-citationPath‐seq identifies an essential mycolate remodeling program for mycobacterial host adaptation
Peterson, E. J., Bailo, R., Rothchild, A. C., Arrieta‐Ortiz, M. L., Kaur, A., Pan, M., Mai, D., Abidi, A. A., Cooper, C., Aderem, A., et al. (2019) · Molecular Systems Biology · doi:10.15252/msb.20188584 · Cited by 63
Transcriptome analysis of mouse aortae reveals multiple novel pathways regulated by aging
Gao, P., Gao, P., Choi, M., Chegireddy, K., Slivano, O. J., Zhao, J., Zhang, W., & Long, X. (2020) · Aging · doi:10.18632/aging.103652 · Cited by 21
Metadata
- Authors
- Moreira-Teixeira, L., Mayer-Barber, K., Sher, A., & O’Garra, A.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2018-04-17
- Volume
- 215
- Issue
- 5
- Pages
- 1273-1285
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2799364359
- Cited by
- 282
- References
- 118
- FWCI
- 17.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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