The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease
Open accessAbstract
Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell types, these IFN-induced GTPases assemble into large nanomachines that execute distinct host defense activities against a wide variety of microbial pathogens. In addition, GBPs customize inflammasome responses to bacterial infection and sepsis, where they act as critical rheostats to amplify innate immunity and regulate tissue damage. Similar functions are becoming evident for metabolic inflammatory syndromes and cancer, further underscoring the importance of GBPs within infectious as well as altered homeostatic settings. A better understanding of the basic biology of these IFN-induced GTPases could thus benefit clinical approaches to a wide spectrum of important human diseases.
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · cited 1×
“Pioneering work by the Darnell group showed that GAS elements were occupied by STAT1 homodimers following IFN-γ treatment, for example, in the human GBP1 promoter (Darnell et al., 1994).”
BackgroundInfluentialNLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500
A guide to immunometabolism for immunologists
O'Neill, L. A. J., Kishton, R. J., & Rathmell, J. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.70 · Cited by 3,315
Approaching the Asymptote? Evolution and Revolution in Immunology
Janeway, C. A. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,252
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
Hotchkiss, R. S., Monneret, G., & Payen, D. (2013) · Nature Reviews Immunology · doi:10.1038/nri3552 · Cited by 2,772
Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712
Inflammation, metaflammation and immunometabolic disorders
Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570
Cited by
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms
Wandel, M. P., Kim, B.-H., Park, E.-S., Boyle, K. B., Nayak, K., Lagrange, B., Herod, A., Henry, T., Zilbauer, M., Rohde, J., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0697-2 · Cited by 284
Self-citationSintov, E., Nikolskiy, I., Barrera, V., Hyoje-Ryu Kenty, J., Atkin, A. S., Gerace, D., Ho Sui, S. J., Boulanger, K., & Melton, D. A. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.08.002 · Cited by 45
Sato, T., Shimizu, T., Fujita, H., Imai, Y., Drucker, D. J., Seino, Y., & Yamada, Y. (2020) · Endocrinology · doi:10.1210/endocr/bqaa201 · Cited by 29
Loss of Function Mutation in ELF4 Causes Autoinflammatory and Immunodeficiency Disease in Human
Sun, G., Qiu, L., Yu, L., An, Y., Ding, Y., Zhou, L., Wu, J., Yang, X., Zhang, Z., Tang, X., et al. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-022-01243-3 · Cited by 23
Côrte-Real, J. V., Baldauf, H.-M., Melo-Ferreira, J., Abrantes, J., & Esteves, P. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.752186 · Cited by 15
Metadata
- Authors
- Tretina, K., Park, E.-S., Maminska, A., & MacMicking, J. D.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2019-02-12
- Volume
- 216
- Issue
- 3
- Pages
- 482-500
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2914381860
- Cited by
- 334
- References
- 165
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tretina, K., Park, E.-S., Maminska, A., & MacMicking, J. D. (2019). Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20182031
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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