The DOI matches its Crossref record; 117 of the 118 references it cites were found in a registry or an index.
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis
Open accessAbstract
Inflammation exerts multiple effects on the early hematopoietic compartment. Best studied is the role of proinflammatory cytokines in activating adult hematopoietic stem and progenitor cells to dynamically replenish myeloid lineage cells in a process known as emergency myelopoiesis. However, it is increasingly appreciated that the same proinflammatory signaling pathways are used in diverse hematopoietic scenarios. This review focuses on inflammatory signaling in the emergence of the definitive hematopoietic compartment during embryonic life, and tonic inflammatory signals derived from commensal microbiota in shaping the adult hematopoietic compartment in the absence of pathogenic insults. Insights into the unique and shared aspects of inflammatory signaling that regulate hematopoietic stem and progenitor cell function across the lifespan and health span of an individual will enable better diagnostic and therapeutic approaches to hematopoietic dysregulation and malignancies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
““Emergency” myelopoiesis is a critical response to physiological insults that supplies the host with enough innate immune cells to fight infections and/or contribute to the repair and immunosurveillance of damaged tissues (Caiado et al., 2021; Collins et al., 2021).”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as Collins et al., 2021
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Signals from the gut microbiota to distant organs in physiology and disease
Schroeder, B. O., & Bäckhed, F. (2016) · Nature Medicine · doi:10.1038/nm.4185 · Cited by 1,409
IFNα activates dormant haematopoietic stem cells in vivo
Essers, M. A. G., Offner, S., Blanco-Bose, W. E., Waibler, Z., Kalinke, U., Duchosal, M. A., & Trumpp, A. (2009) · Nature · doi:10.1038/nature07815 · Cited by 1,368
Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
Chen, M. J., Yokomizo, T., Zeigler, B. M., Dzierzak, E. A., & Speck, N. A. (2009) · Nature · doi:10.1038/nature07619 · Cited by 1,030
Haematopoietic stem cells derive directly from aortic endothelium during development
Bertrand, J. Y., Chi, N. C., Santoso, B., Teng, S., Stainier, D. Y. R., & Traver, D. (2010) · Nature · doi:10.1038/nature08738 · Cited by 1,025
Blood stem cells emerge from aortic endothelium by a novel type of cell transition
Kissa, K., & Herbomel, P. (2010) · Nature · doi:10.1038/nature08761 · Cited by 961
Lieschke, G. J., Grail, D., HODGSON, G. S., Metcalf, D., Stanley, E. G., Cheers, C., Fowler, K., Basu, S., Zhan, Y., & Dunn, A. (1994) · Blood · doi:10.1182/blood.v84.6.1737.1737 · Cited by 956
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
Boisset, J.-C., van Cappellen, W. A., Andrieu‐Soler, C., Galjart, N., Dzierzak, E. A., & Robin, C. (2010) · Nature · doi:10.1038/nature08764 · Cited by 951
Cited by
Sorted by citations
Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands
Kasbekar, M., Mitchell, C. A., Proven, M. A., & Passegue, E. A. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.013 · Cited by 130
Self-citationThe impact of interleukin-6 (IL-6) and mesenchymal stem cell-derived IL-6 on neurological conditions
Kerkis, I., da Silva, Á. R. D. B. P., & Araldi, R. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1400533 · Cited by 94
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Hegde, S., Giotti, B., Soong, B. Y., Halász, L., Bérichel, J. L., Schaefer, M. M., Kloeckner, B., Mattiuz, R., Park, M. D., Magen, A., et al. (2025) · Nature · doi:10.1038/s41586-025-09493-y · Cited by 52
Maternal inflammation regulates fetal emergency myelopoiesis
Collins, A., Swann, J. W., Proven, M. A., Patel, C. M., Mitchell, C. A., Kasbekar, M., Dellorusso, P. V., & Passegue, E. A. (2024) · Cell · doi:10.1016/j.cell.2024.02.002 · Cited by 39
Self-citationSanchez, J. F., Maknojia, A., & King, K. Y. (2024) · Blood · doi:10.1182/blood.2023021174 · Cited by 41
Metadata
- Authors
- Collins, A., Mitchell, C. A., & Passegué, E.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY 1
- Corresponding author
- Collins, Amélie
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2021-06-15
- Volume
- 218
- Issue
- 7
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC8210624
- OpenAlex
- W3168900950
- Cited by
- 111
- References
- 118
- Citations by year
- 2026: 24 · 2025: 24 · 2024: 32 · 2023: 22 · 2022: 8 · 2021: 1
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K08-DK124657)
- Louis V. Gerstner Jr. Scholar Award
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R35-HL135763)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- inflammatory signaling, hematopoietic stem and progenitor cells, emergency myelopoiesis, inflammatory cytokines, definitive hematopoiesis, embryonic hematopoiesis, commensal microbiota, hematopoietic homeostasis, myeloid lineage, hematologic malignancies
- MeSH terms
- Animals, Hematopoiesis, Hematopoietic Stem Cells, Homeostasis, Humans, Inflammation, Stem Cells, Signal Transduction, Myeloid Cells, Myelopoiesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
