The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord
Open accessAbstract
The wound healing process that occurs after spinal cord injury is critical for maintaining tissue homeostasis and limiting tissue damage, but eventually results in a scar-like environment that is not conducive to regeneration and repair. A better understanding of this dichotomy is critical to developing effective therapeutics that target the appropriate pathobiology, but a major challenge has been the large cellular heterogeneity that results in immensely complex cellular interactions. In this study, we used single-cell RNA sequencing to assess virtually all cell types that comprise the mouse spinal cord injury site. In addition to discovering novel subpopulations, we used expression values of receptor–ligand pairs to identify signaling pathways that are predicted to regulate specific cellular interactions during angiogenesis, gliosis, and fibrosis. Our dataset is a valuable resource that provides novel mechanistic insight into the pathobiology of not only spinal cord injury but also other traumatic disorders of the CNS.
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Cited by
Spinal cord injury: molecular mechanisms and therapeutic interventions
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Metadata
- Authors
- Milich, L. M., Choi, J. S., Ryan, C., Cerqueira, S. R., Benavides, S., Yahn, S. L., Tsoulfas, P., & Lee, J. K.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2021-06-16
- Volume
- 218
- Issue
- 8
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W3166004065
- Cited by
- 283
- References
- 71
- FWCI
- 23.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Milich, L. M., Choi, J. S., Ryan, C., Cerqueira, S. R., Benavides, S., Yahn, S. L., Tsoulfas, P., & Lee, J. K. (2021). Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20210040
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