CONDITIONS DETERMINING THE TRANSPLANTABILITY OF TISSUES IN THE BRAIN
Open accessAbstract
In confirmation of Shirai's observation, we find that transplantable mouse tumors grow actively when inoculated into the brains of rats, guinea pigs, and pigeons, whereas subcutaneous or intramuscular grafts in the same animals fail. This growth of foreign tissue in the brain, however, takes place only when the grafted material lies entirely in the brain tissue; if it comes in contact with the ventricle a cellular reaction takes place with resultant destruction of the graft. The growth of foreign tissue in the brain may be completely inhibited by simultaneous inoculations of a small bit of autologous but not by a bit of homologous spleen tissue. Mice highly immune to subcutaneous transplants of mouse cancer show no resistance to such tumors when the inoculation is made into the brain. Although the brain is without obvious power of resistance to implants of transplantable heteroplastic mouse tumors, yet grafts of spontaneous tumors fail to grow there even, as a rule, when tumor implanted and animal host are of the same species.
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Mouse sarcoma cells grow rapidly when injected into the brain parenchyma of rats but are immunologically rejected when placed close to a ventricle.
“early studies demonstrated that mouse sarcoma cells grow rapidly when injected into the brain parenchyma of rats but were immunologically rejected when placed close to a ventricle [a space filled with cerebrospinal fluid (CSF)] (2).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [2]
The development of robust immune reactions against parenchymal antigens depends on their entry into fluid spaces, which promotes egress into draining lymph nodes.
“These findings show that the development of robust immune reactions against parenchymal antigens depends on their entry into fluid spaces, which promotes egress into draining lymph nodes.”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [2]
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Cites
TRANSPLANTABILITY OF TISSUES TO THE EMBRYO OF FOREIGN SPECIES
Murphy, J. B. (1913) · The Journal of Experimental Medicine · doi:10.1084/jem.17.4.482 · Cited by 163 · see citing works
Self-citationFACTORS OF RESISTANCE TO HETEROPLASTIC TISSUE-GRAFTING
Murphy, J. B. (1914) · The Journal of Experimental Medicine · doi:10.1084/jem.19.5.513 · Cited by 74 · see citing works
Self-citationAN EXPERIMENTAL COMPARISON OF TRANSPLANTED TUMOR AND A TRANSPLANTED NORMAL TISSUE CAPABLE OF GROWTH
Rous, P. (1910) · The Journal of Experimental Medicine · doi:10.1084/jem.12.3.344 · Cited by 42 · see citing works
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What is immune privilege (not)?
Galea, I., Bechmann, I., & Perry, V. H. (2007) · Trends in Immunology · doi:10.1016/j.it.2006.11.004 · Cited by 768 · see citing works
Revisiting the Mechanisms of CNS Immune Privilege
Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682 · see citing works
What is the blood–brain barrier (not)?
Bechmann, I., Galea, I., & Perry, V. H. (2007) · Trends in Immunology · doi:10.1016/j.it.2006.11.007 · Cited by 520 · see citing works
The anatomy and immunology of vasculature in the central nervous system
Mastorakos, P., & McGavern, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav0492 · Cited by 333 · see citing works
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Elmer, B. M., & McAllister, A. K. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.001 · Cited by 196 · see citing works
Habashy, K. J., Mansour, R., Moussalem, C., Sawaya, R., & Massaad, M. J. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01864-w · Cited by 95 · see citing works
CD8 T Cell–Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas
Murphy, K., & Griffith, T. (2016) · Cancers · doi:10.3390/cancers8080071 · Cited by 11 · see citing works
- Authors
- Murphy, J. B., & Sturm, E.
- Affiliations
- From the Laboratories of The Rockefeller Institute for Medical Research.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1923-08-01
- Volume
- 38
- Issue
- 2
- Pages
- 183-197
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2128434
- OpenAlex
- W2121080034
- Cited by
- 246
- References
- 3
- Citations by year
- 2026: 12 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 9 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 6
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- neural transplantation, transplantability, mouse tumors, brain grafts, ventricles, graft rejection, cellular response, spleen transplantation, autologous transplantation, heterologous transplantation
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