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PREVENTION OF PNEUMOCOCCAL PNEUMONIA BY IMMUNIZATION WITH SPECIFIC CAPSULAR POLYSACCHARIDES
Open accessAbstract
1. Immunization of man with 0.03 to 0.06 mg. of each of the capsular polysaccharides of pneumococcus types I, II, V, and VII, given in a single subcutaneous injection, has been shown to be effective in preventing pneumonia caused by these types but not that due to heterologous types. 2. Immunity appears within a period of 2 weeks following injection of the polysaccharides. Its duration was not determined, although 6 months can be set as a minimum. 3. Immunization of alternate subjects in the population reduced greatly the incidence of pneumonia in the non-immunized. 4. The carrier rate for pneumococcus types I, II, V, and VII was lowered significantly in the immunized group as compared with the controls. It is suggested that an over-all reduction in the incidence of carriers was responsible for the lowered rates for pneumococcal pneumonia in the non-immunized group.
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Citations
Cited by
Hao (2015) · doi:10.1002/14651858 · Cited by 11,321
Pneumococcal Disease during HIV Infection: Epidemiologic, Clinical, and Immunologic Perspectives
Janoff, E. N., Breiman, R. F., Daley, C. L., & Hopewell, P. C. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-4-314 · Cited by 323
The Immune Response to Pneumococcal Proteins during Experimental Human Carriage
McCool, T. L., Cate, T. R., Moy, G., & Weiser, J. N. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011576 · Cited by 270
Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization
McCool, T. L., & Weiser, J. N. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5807-5813.2004 · Cited by 153
Metadata
- Authors
- MacLeod, C. M., Hodges, R. G., Heidelberger, M., & Bernhard, W. G.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1945-12-01
- Volume
- 82
- Issue
- 6
- Pages
- 445-465
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1973815343
- Cited by
- 518
- References
- 0
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: PREVENTION OF PNEUMOCOCCAL PNEUMONIA BY IMMUNIZATION WITH SPECIFIC CAPSULAR POLYSACCHARIDES. https://app.cochat.ai/papers/10.1084/jem.82.6.445
- The paper
- MacLeod, C. M., Hodges, R. G., Heidelberger, M., & Bernhard, W. G. (1945). PREVENTION OF PNEUMOCOCCAL PNEUMONIA BY IMMUNIZATION WITH SPECIFIC CAPSULAR POLYSACCHARIDES. Journal of Experimental Medicine. https://doi.org/10.1084/jem.82.6.445
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
