Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization

McCool, Tera L.; Weiser, Jeffrey N.

doi:10.1128/iai.72.10.5807-5813.2004

Cited by 153Pneumonia and Respiratory InfectionsBacterial Infections and VaccinesMicrobial infections and disease research

Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization

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McCool, Tera L., Weiser, Jeffrey N.·2004·Infection and Immunity

DOI 10.1128/iai.72.10.5807-5813.2004PMC PMC517579

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Abstract

Colonization is the first step in the interaction between Streptococcus pneumoniae and its human host. To better understand the mechanisms contributing to natural carriage, a mouse model of pneumococcal colonization was developed with a clinical isolate of S. pneumoniae previously characterized in experimental colonization of humans. Similar to carriage events in humans, colonization of mice was self-limited and there was no evidence of lower respiratory tract or invasive disease. Carriage induced a serum antibody response to whole pneumococci that was associated temporally with clearance of colonization in three inbred strains of mice. Individual mice, however, did not demonstrate a correlation between the density of colonization and amounts of serum or of mucosal antibodies, including antibodies of different isotypes and antigenic specificities. The role of antibody in the clearance of carriage was then examined in mice with genetic defects in humoral immunity. xid mice, which have deficient responses to polysaccharide antigens, cleared colonization at the same rate as the parent strain. Finally, we showed that μMT mice, which lack mature B cells and fail to produce antibody, were unaffected in the density or duration of colonization. These results demonstrate that antibody is not required for clearance of pneumococcal colonization in mice.

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Strain P1121 efficiently colonizes the murine nasopharynx.
“Strain P1121, a type 23F isolate obtained from a study of experimental human colonization, was selected for its ability to efficiently colonize the murine nasopharynx (15,16,18).”
From Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice (2011) · cites this paper as [16]

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“All pneumococcal infection, however, begins with colonization of the mucosal surface of the nasopharynx, a state far more common than host-pathogen interactions leading to disease (2, 5, 32).”
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Brief Definitive Report The Immune Response to Pneumococcal Proteins during Experimental Human Carriage
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Authors: McCool, T. L., & Weiser, J. N.
Affiliations: University of Pennsylvania (US)
Corresponding author: Weiser, Jeffrey N.
ORCID: Weiser, Jeffrey N.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2004-10
Volume: 72
Issue: 10
Pages: 5807-5813
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.72.10.5807-5813.2004
PMC: PMC517579
OpenAlex: W2153114735
Cited by: 153
References: 37
Citations by year: 2026: 5 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 13 · 2013: 6 · 2012: 14
FWCI: 6.23
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01ai30040-13-0-5)
National Institute of Allergy and Infectious Diseases (R01AI038446, AI 38446, R21AI044231, F32AI051115, AI30040, AI51115, R01AI044231, AI44231, N01 AI030040)
Topics: Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords: Streptococcus pneumoniae, pneumococcal carriage, antibody-mediated clearance, humoral immunity, xid mice, B cell deficiency, polysaccharide antigens, mucosal antibodies, inbred mouse strains
MeSH terms: Animals, Antibodies, Bacterial, Antibody Formation, Antibody Specificity, Antigens, Bacterial, B-Lymphocytes, Bacterial Proteins, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Humans, Immune Sera, Immunoglobulin Isotypes, Mice, Inbred Strains, Pneumococcal Infections, Species Specificity, Streptococcus pneumoniae, Immunity, Mucosal, Mice

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Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization

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