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THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS
Open accessAbstract
1. A picture resembling acute disseminated encephalomyelitis in the human being has been regularly and rapidly produced in rhesus monkeys by injection of emulsions of adult rabbit and monkey brain administered with adjuvants. 2. No lesions of the central nervous system resulted from injection of similar emulsions of fetal rabbit brain or adult rabbit lung. 3. A description of the gross and histological findings in the central nervous system is given and compared with features of human demyelinating disease. 4. The experimental findings are in accord with the hypothesis that antibody to the injected brain emulsion reacts with the tissues of the nervous system of the animal to produce the pathological changes.
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Citations
Cited by
Active induction of experimental allergic encephalomyelitis
Stromnes, I. M., & Goverman, J. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.285 · Cited by 573
CHRONIC THYROIDITIS AND AUTOIMMUNIZATION
Witebsky, E. (1957) · Journal of the American Medical Association · doi:10.1001/jama.1957.02980130015004 · Cited by 547
HUMAN AUTO-IMMUNE THYROIDITIS: SEROLOGICAL STUDIES
ROITT, I. (1958) · The Lancet · doi:10.1016/s0140-6736(58)90530-0 · Cited by 337
THE ENCEPHALOMYELITIC ACTIVITY OF MYELIN ISOLATED BY ULTRACENTRIFUGATION
Laatsch, R. H., Kies, M. W., Gordon, S., & Alvord, E. C. (1962) · The Journal of Experimental Medicine · doi:10.1084/jem.115.4.777 · Cited by 300
Ronchi, F., Basso, C., Preite, S., Reboldi, A., Baumjohann, D., Perlini, L., Lanzavecchia, A., & Sallusto, F. (2016) · Nature Communications · doi:10.1038/ncomms11541 · Cited by 115
Metadata
- Authors
- Kabat, E. A., Wolf, A., & Bezer, A. E.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1947-01-01
- Volume
- 85
- Issue
- 1
- Pages
- 117-130
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1991361780
- Cited by
- 403
- References
- 0
- FWCI
- 67.88
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS. https://app.cochat.ai/papers/10.1084/jem.85.1.117
- The paper
- Kabat, E. A., Wolf, A., & Bezer, A. E. (1947). THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS. Journal of Experimental Medicine. https://doi.org/10.1084/jem.85.1.117
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
