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A NEW METHOD FOR THE GENERATION AND USE OF FOCUSED ULTRASOUND IN EXPERIMENTAL BIOLOGY
Open accessAbstract
1. An efficient generator of focused ultrasound has been designed, built, and successfully operated. 2. The generator has been used to produce focal heating in the centers of paraffin blocks, and in a similar manner, focal areas of destruction were obtained deep in fresh liver tissue with minimal effects at the surface and no effects on the intervening tissue. 3. In animals, focused ultrasound of high intensity produced local cerebral changes as inferred from behavior disabilities and as demonstrated at autopsy. This local brain effect was achieved through intervening scalp, skull, and meninges. The resulting behavior disabilities disappeared in from 2 to 16 hours. 4. To date, it has not been possible to produce such brain changes without incidental injury to the skin and subcutaneous tissue lying at the base of the cone of radiation. 5. Improvements in generation and application of the focused supersonic beam are suggested whereby it should be possible to increase still further the focal effects in the brain, with a corresponding decrease or elimination of complicating surface injury.
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Citations
Cited by
Therapeutic applications of ultrasound
ter Haar, G. (2007) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.07.005 · Cited by 721
McDannold, N., Clement, G. T., Black, P., Jolesz, F., & Hynynen, K. (2010) · Neurosurgery · doi:10.1227/01.neu.0000360379.95800.2f · Cited by 555
McDannold, N., Vykhodtseva, N., Raymond, S., Jolesz, F. A., & Hynynen, K. (2005) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2005.07.010 · Cited by 323
A Historical Review of Brain Drug Delivery
Pardridge, W. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061283 · Cited by 219
Focused ultrasound for neuromodulation
Darrow, D. P. (2019) · Neurotherapeutics · doi:10.1007/s13311-018-00691-3 · Cited by 190
Metadata
- Authors
- Lynn, J. G., Zwemer, R. L., Chick, A. J., & Miller, A. E.
- Venue
- Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 1942-11-20
- Volume
- 26
- Issue
- 2
- Pages
- 179-193
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W2065685950
- Cited by
- 690
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A NEW METHOD FOR THE GENERATION AND USE OF FOCUSED ULTRASOUND IN EXPERIMENTAL BIOLOGY. https://app.cochat.ai/papers/10.1085/jgp.26.2.179
- The paper
- Lynn, J. G., Zwemer, R. L., Chick, A. J., & Miller, A. E. (1942). A NEW METHOD FOR THE GENERATION AND USE OF FOCUSED ULTRASOUND IN EXPERIMENTAL BIOLOGY. Journal of General Physiology. https://doi.org/10.1085/jgp.26.2.179
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
