Focused ultrasound for neuromodulation
Open accessAbstract
For more than 70 years, the promise of noninvasive neuromodulation using focused ultrasound has been growing while diagnostic ultrasound established itself as a foundation of clinical imaging. Significant technical challenges have been overcome to allow transcranial focused ultrasound to deliver spatially restricted energy into the nervous system at a wide range of intensities. High-intensity focused ultrasound produces reliable permanent lesions within the brain, and low-intensity focused ultrasound has been reported to both excite and inhibit neural activity reversibly. Despite intense interest in this promising new platform for noninvasive, highly focused neuromodulation, the underlying mechanism remains elusive, though recent studies provide further insight. Despite the barriers, the potential of focused ultrasound to deliver a range of permanent and reversible neuromodulation with seamless translation from bench to the bedside warrants unparalleled attention and scientific investment. Focused ultrasound boasts a number of key features such as multimodal compatibility, submillimeter steerable focusing, multifocal, high temporal resolution, coregistration, and the ability to monitor delivered therapy and temperatures in real time. Despite the technical complexity, the future of noninvasive focused ultrasound for neuromodulation as a neuroscience and clinical platform remains bright.
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HIFU produces permanent lesions by coagulating cellular proteins and thermal ablation.
“HIFU creates permanent lesions through coagulation of cellular proteins and thermal ablation [58]”
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Focused Ultrasound-Induced Suppression of Auditory Evoked Potentials in Vivo
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Neuromodulation by nanozymes and ultrasound during Alzheimer’s disease management
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Ultrasound in Traumatic Spinal Cord Injury: A Wide-Open Field
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Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients
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Oscillatory behavior of microbubbles impacts efficacy of cellular drug delivery
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Weak Ultrasound Contributes to Neuromodulatory Effects in the Rat Motor Cortex
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Focused ultrasound and other lesioning in the treatment of tremor.
Binder, D., Shah, B., & Elias, W. (2022) · Journal of Neurological Sciences · doi:10.1016/j.jns.2022.120193 · Cited by 28 · see citing works
Transcranial Ultrasound Stimulation of Hypothalamus in Aging Mice
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Numerical Evaluation of the Influence of Skull Heterogeneity on Transcranial Ultrasonic Focusing
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A Dual-Mode 2D Matrix Array for Ultrasound Image-Guided Noninvasive Therapy
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The Emergence of Functional Ultrasound for Noninvasive Brain–Computer Interface
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New neuromodulation techniques for treatment resistant depression
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Noninvasive ultrasound stimulation to treat myocarditis through splenic neuro-immune regulation
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Transcranial ultrasound stimulation applied in ischemic stroke rehabilitation: A review
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Histotripsy: A Promising Modality for Cancer Treatment
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New Cognitive Neurotechnology Facilitates Studies of Cortical–Subcortical Interactions
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Tunable acoustic metasurface for broadband asymmetric focusing based on Helmholtz resonator
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Non-invasive stimulation of the social brain: the methodological challenges
Penton, T., Catmur, C., Banissy, M. J., Bird, G., & Walsh, V. (2022) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa102 · Cited by 21 · see citing works
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Effects of Low-Intensity Transcranial Pulsed Ultrasound Treatment in a Model of Alzheimer's Disease
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Modeling ultrasound modulation of neural function in a single cell
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Ultrasound Stimulation of Periaqueductal Gray Induces Defensive Behaviors
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Looking beyond the opioid receptor: A desperate need for new treatments for opioid use disorder
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Recent developments in imaging of epilepsy
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Nanoparticle-based optical interfaces for retinal neuromodulation: a review
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Indications for MRI in fetal isolated mild ventriculomegaly… ‘And then, there were none’
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Therapeutic ultrasound: The future of epilepsy surgery?
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Focused ultrasound for functional neurosurgery
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Histological examination of focused ultrasound effects on human brain tissue
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Emerging therapies for neuromodulation in Parkinson's disease
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Functional material-mediated wireless physical stimulation for neuro-modulation and regeneration
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- Authors
- Darrow, D. P.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Darrow, David P
- ORCID
- Darrow, David P
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 16
- Issue
- 1
- Pages
- 88-99
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC6361056
- OpenAlex
- W2902574161
- Cited by
- 190
- References
- 125
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 24 · 2023: 36 · 2022: 33 · 2021: 18 · 2020: 12 · 2019: 9 · 2018: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Keywords
- focused ultrasound, neuromodulation, transcranial ultrasound, non-invasive brain stimulation, high-intensity focused ultrasound, low-intensity focused ultrasound, multimodal imaging, real-time temperature monitoring, mechanism of action
- MeSH terms
- Animals, Brain, Humans, Ultrasonic Therapy
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