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Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride
Open accessAbstract
The injection of tetraethylammonium chloride into the giant axon of the squid prolongs the action potential and eliminates most of the late current under voltage-clamp. Experiments on fibers in an external medium of high potassium ion concentration demonstrate that injected tetraethylammonium chloride causes rectification of the instantaneous current-voltage curve for potassium by excluding outward current. This interference with the flow of outward potassium ion current underlies the prolongation of the action potential seen in tetraethylammonium-injected fibers.
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Citations
Cited by
Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons
Armstrong, C. M. (1971) · The Journal of General Physiology · doi:10.1085/jgp.58.4.413 · Cited by 929
Self-citationExcitatory synaptic interactions between CA3 neurones in the guinea‐pig hippocampus.
Miles, R., & Wong, R. K. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016055 · Cited by 503
Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block
Wang, C., Takeuchi, K., Pinto, L. H., & Lamb, R. A. (1993) · Journal of Virology · doi:10.1128/jvi.67.9.5585-5594.1993 · Cited by 494
The aromatic binding site for tetraethylammonium ion on potassium channels
Heginbotham, L., & MacKinnon, R. (1992) · Neuron · doi:10.1016/0896-6273(92)90276-j · Cited by 451
Oertel, D. (1983) · The Journal of Neuroscience · doi:10.1523/jneurosci.03-10-02043.1983 · Cited by 296
Metadata
- Authors
- Armstrong, C. M., & Binstock, L.
- Venue
- The Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 1965-05-01
- Volume
- 48
- Issue
- 5
- Pages
- 859-872
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W2398410876
- Cited by
- 436
- References
- 0
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Armstrong, C. M., & Binstock, L. (1965). Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride. The Journal of General Physiology. https://doi.org/10.1085/jgp.48.5.859
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
