The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block
Open accessAbstract
The influenza A virus M2 integral membrane protein has ion channel activity which can be blocked by the antiviral drug amantadine. The M2 protein transmembrane domain is highly conserved in amino acid sequence for all the human, swine, equine, and avian strains of influenza A virus, and thus, known amino acid differences could lead to altered properties of the M2 ion channel. We have expressed in oocytes of Xenopus laevis the M2 protein of human influenza virus A/Udorn/72 and the avian virus A/chicken/Germany/34 (fowl plague virus, Rostock) and derivatives of the Rostock ion channel altered in the presumed pore region. The pH of activation of the M2 ion channels and amantadine block of the M2 ion channels were investigated. The channels were found to be activated by pH in a similar manner but differed in their apparent Kis for amantadine block.
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Higuchi, R., Krummel, B., & Saiki, R. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.15.7351 · Cited by 2,387
DeLean, A., Munson, P. J., & Rodbard, D. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.235.2.e97 · Cited by 2,374
Influenza virus M2 protein has ion channel activity
Pinto, L. H., Holsinger, L. J., & Lamb, R. A. (1992) · Cell · doi:10.1016/0092-8674(92)90452-i · Cited by 1,213
Self-citationThe molecular basis of the specific anti-influenza action of amantadine.
Hay, A. J., Wolstenholme, A. J., Skehel, J. J., & Smith, M. H. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04038.x · Cited by 847
Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.
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Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface
Lamb, R. A., Zebedee, S. L., & Richardson, C. D. (1985) · Cell · doi:10.1016/0092-8674(85)90211-9 · Cited by 576
Self-citationZebedee, S. L., & Lamb, R. A. (1988) · Journal of Virology · doi:10.1128/jvi.62.8.2762-2772.1988 · Cited by 520
Self-citationThe Selective Inhibition of Delayed Potassium Currents in Nerve by Tetraethylammonium Ion
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Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride
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Cited by
Luo, W., & Hong, M. (2010) · Journal of the American Chemical Society · doi:10.1021/ja9096219 · Cited by 90
Metadata
- Authors
- Wang, C., Takeuchi, K., Pinto, L. H., & Lamb, R. A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1993-09
- Volume
- 67
- Issue
- 9
- Pages
- 5585-5594
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1585610099
- Cited by
- 494
- References
- 25
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, C., Takeuchi, K., Pinto, L. H., & Lamb, R. A. (1993). Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. Journal of Virology. https://doi.org/10.1128/jvi.67.9.5585-5594.1993
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
